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Characterizing Myocardial Edema and Hemorrhage Using Quantitative T2 and T2* Mapping at Multiple Time Intervals Post ST Elevation Myocardial Infarction.
MedLine Citation:
PMID:  22744938     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Accurate characterization of the longitudinal trends of myocardial edema and hemorrhage has been previously limited by subjective qualitative methods. We aimed to prospectively characterize the evolution of myocardial edema and hemorrhage post acute myocardial infarction using quantitative measures. METHODS AND RESULTS: -Sixty-two patients were enrolled post primary percutaneous coronary intervention and underwent cardiovascular magnetic resonance on a 1.5T scanner at 48 hours, 3 weeks and 6 months. Myocardial edema and hemorrhage were assessed by T2 and T2* mapping respectively in both infarct segment (IS) and remote segment (RS). At 48 hours, T2 is higher in IS compared to RS (56.7 ms vs. 43.4 ms, p<0.01). At 3 weeks T2 remains higher in IS compared to RS (51.8 ms vs. 39.5 ms, p<0.01) and subsequently equalizes by 6 months (39.8 ms vs. 39.5 ms, p=NS). T2 is also increased in RS at day 2 versus 3 weeks (43.4 ms vs. 39.5 ms, p<0.01). At 48 hours T2* was reduced in IS compared to RS (32.4 ms vs. 37.4 ms, p<0.01). At 3 weeks (IS 37.7 ms vs. RS 38.4 ms, p=NS) and 6 months (IS 37.3 ms vs. RS 38.2 ms, p=NS), T2* values were equal in both segments. CONCLUSIONS: -Quantification of myocardial edema and hemorrhage by T2 and T2* mapping is feasible post acute myocardial infarction and demonstrates that hemorrhage resolves faster than edema. Non-infarcted segments can also demonstrate edema in the acute phase possibly due to global hyperemia.
Mohammad I Zia; Nilesh R Ghugre; Kim A Connelly; Bradley H Strauss; John D Sparkes; Alexander J Dick; Graham A Wright
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  -     ISSN:  1942-0080     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Toronto East General Hospital, Sunnybrook Health Sciences Centre, Univ of Toronto, Toronto, Ontario, Canada;
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