Document Detail

Characterizing mechanical properties of biological cells by microinjection.
MedLine Citation:
PMID:  20525536     Owner:  NLM     Status:  MEDLINE    
Microinjection has been demonstrated to be an effective technique to introduce foreign materials into biological cells. Despite the advance, whether cell injection can be used to characterize the mechanical properties of cells remains elusive. In this paper, extending the previously developed mechanical model, various constitutive materials are adopted to present the membrane characteristics of cells. To demonstrate the modeling approach and identify the most appropriate constitutive material for a specific biomembrane, finite element analysis (FEA) and experimental tests are carried out. It is shown that the modeling results agree well with those from both FEA and experiments, which demonstrates the validity of the developed approach. Moreover, Yeoh and Cheng materials are found to be the best constitutive materials in representing the deformation behaviors of zebrafish embryos and mouse embryos (or oocytes), respectively. Also, the mechanical properties of zebrafish embryos at different developmental stages and mouse embryos (or oocytes) are characterized.
Youhua Tan; Dong Sun; Wenhao Huang; Shuk Han Cheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-03
Journal Detail:
Title:  IEEE transactions on nanobioscience     Volume:  9     ISSN:  1558-2639     ISO Abbreviation:  IEEE Trans Nanobioscience     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101152869     Medline TA:  IEEE Trans Nanobioscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  171-80     Citation Subset:  IM    
Mechatronics and Automation Group, Suzhou Joint Research Centre of City University of Hong Kong and University of Science and Technology of China, Suzhou 215123, China.
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MeSH Terms
Biomechanics / physiology*
Cell Membrane / physiology*
Cell Shape / physiology*
Elastic Modulus
Embryo, Mammalian
Embryo, Nonmammalian
Finite Element Analysis
Models, Biological*
Reproducibility of Results
Shear Strength

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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