Document Detail

Characterization of the upper limb arterial properties during reactive hyperemia.
MedLine Citation:
PMID:  17676391     Owner:  NLM     Status:  MEDLINE    
The radial artery (RA) pressure waveform is commonly used to reconstruct the central aortic pressure waveform. Because the RA pressure waveform has been used as input to this process, its features that are dependent on the local arterial properties can influence the final reconstructed aortic waveform. In this study, we determined the effects of altered upper limb pulse wave velocity (PWV) and local wave reflection parameters on RA pressure waveform augmentation (RA-AIx). Twenty healthy volunteers (10 men) between the ages of 18 and 35 years of age were recruited. Simultaneous pressure waveforms were acquired using arterial tonometers from the right carotid and the radial arteries, prior to and following tourniquet induced hyperemia. The phase velocities from the pressure wave transfer function were used to estimate the pulse wave velocity (PWV(infinity)), the local reflection coefficient (Gamma) and an estimate of the terminal impedance of the upper limbs, PWV(0+). The RA-AIx was represented as a linear, three-parameter model that included the input (the AIx of the carotid artery pressure waveform, CA-AIx), the Gamma and PWV(infinity) of the arm. Tourniquet induced hyperemia did not alter Gamma but reduced PWV(infinity), and PWV(0+) and increased RA-AIx. Multiple linear regression analysis indicated that RA-AIx was increased by high levels of CA-AIx and PWV(infinity) and decreased by elevated Gamma. The relative weighing of CA-AIx, Gamma and PWV(infinity) on RA-AIx were 3:2:1, respectively. The AIx of RA is determined to an equal extent by the input and local factors. Interpretation of the AIx of the RA and the reconstructed central aortic waveform should be made in the context of this relationship.
Gary Dobson; Michael Chong; Michelle Walker; Paul Petrasek; Clifton R Johnston; John V Tyberg; Mustafa Karamanoglu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular engineering (Dordrecht, Netherlands)     Volume:  7     ISSN:  1567-8822     ISO Abbreviation:  Cardiovasc Eng     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-24     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101132083     Medline TA:  Cardiovasc Eng     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  127-34     Citation Subset:  IM    
Department of Anesthesiology, University of Calgary, Calgary, Canada.
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MeSH Terms
Arm / blood supply*,  physiology*
Arteries / physiology*
Blood Flow Velocity / physiology*
Blood Pressure / physiology*
Computer Simulation
Diagnosis, Computer-Assisted
Hyperemia / physiopathology*
Models, Cardiovascular*

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