Document Detail


Characterization of two vasoactive peptides isolated from the plasma of the snake Crotalus durissus terrificus.
MedLine Citation:
PMID:  22483415     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Incubation of plasma from the snake Crotalus durissus terrificus (CDTP) with trypsin generated two hypotensive peptides. The primary structure of the peptides was established for two sequences as: (Ser - Ile - Pro - Gln - Ala - Pro - Thr - Ser - Asn - Leu - Ile - Glu - Ala - Thr - Lys) and (Lys - Pro - Asp - Ala - Asn - Gln - Val - Leu - Ile - Gln - Val - Ile - Gly - Val). These peptides display homology with fragments of albumin from Trimeresurus flavoviridis. Bolus intra-arterial injection of the purified or the synthetic peptide produced a strong and sustained vasopressor response in the anaesthetized snake (CDT) and rats (Wistar); this hypotensive effect was also potentiated by captopril-an angiotensin-converting (0.1mg/kg) enzyme inhibitor.
Authors:
S A Barreto; L C A G Chaguri; B C Prezoto; I Lebrun
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-1
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie     Volume:  -     ISSN:  1950-6007     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-4-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Affiliation:
Biochemistry and Biophysics Laboratory, Butantan Institute, Av. Vital Brazil, 1500, São Paulo, SP, CEP 05503-900, Brazil.
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