| Characterization of tumor microvascular structure and permeability: comparison between magnetic resonance imaging and intravital confocal imaging. | |
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MedLine Citation:
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PMID: 20615006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Solid tumors are characterized by abnormal blood vessel organization, structure, and function. These abnormalities give rise to enhanced vascular permeability and may predict therapeutic responses. The permeability and architecture of the microvasculature in human osteosarcoma tumors growing in dorsal window chambers in athymic mice were measured by confocal laser scanning microscopy (CLSM) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Dextran (40 kDa) and Gadomer were used as molecular tracers for CLSM and DCE-MRI, respectively. A significant correlation was found between permeability indicators. The extravasation rate K(i) as measured by CLSM correlated positively with DCE-MRI parameters, such as the volume transfer constant K(trans) and the initial slope of the contrast agent concentration-time curve. This demonstrates that these two techniques give complementary information. Extravasation was further related to microvascular structure and was found to correlate with the fractal dimension and vascular density. The structural parameter values that were obtained from CLSM images were higher for abnormal tumor vasculature than for normal vessels. |
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Authors:
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Nina Kristine Reitan; Marte Thuen; Pål Erik Goa; Catharina de Lange Davies |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical optics Volume: 15 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-10-29 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 036004 Citation Subset: IM |
Affiliation:
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Norwegian University of Science and Technology, Department of Physics, Hogskoleringen 5, N-7491 Trondheim, Norway. nina.reitan@ntnu.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Neoplasms / blood supply* Capillary Permeability Contrast Media Disease Models, Animal Female Humans Linear Models Magnetic Resonance Imaging / methods* Mice Mice, Inbred BALB C Mice, Nude Microscopy, Confocal / methods* Microvessels / metabolism*, pathology* Neovascularization, Pathologic / pathology Osteosarcoma / blood supply* Structure-Activity Relationship Transplantation, Heterologous |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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