| Characterization of trout galanin and its distribution in trout brain and pituitary. | |
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MedLine Citation:
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PMID: 7532194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Galanin was purified from an extract of the stomach of the rainbow trout, Oncorhynchus mykiss, and its primary structure was established as Gly-Trp-Thr-Leu-Asn-Ser- Ala-Gly-Tyr-Leu10-Leu-Gly-Pro-His-Gly-Ile-Asp-Gly-His-Arg20- Thr-Leu-Ser-Asp- Lys-His-Gly-Leu-Ala. Trout galanin shows six amino acid substitutions compared with pig galanin, but the N-terminal region (residues 1-14) has been fully conserved. The distribution of galanin-immunoreactive (GAL-IR) structures in the trout brain and pituitary was studied via immunohistochemistry. GAL-IR cell bodies were observed only in the caudal telencephalon, the preoptic region, and the mediobasal hypothalamus. GAL-IR fibers, however, are widely distributed throughout the brain, with a much lower density in the midbrain and posterior brain than in the tel- and diencephalon. Particularly dense innervation of the mediobasal hypothalamus, the ventral and supracommissuralis parts of the caudal telencephalon, and the region above and below the anterior commissure was observed. A heavy innervation of the pituitary was consistently detected. GAL-IR fibers were present in neurohypophyseal digitations of both the anterior and intermediate lobes with highest density in the region of the proximal pars distalis, where growth hormone and gonadotropic cells are located. Fibers were also seen in digitations of the rostral pars distalis, in particular between the prolactin follicles. The distribution of GAL-IR neurons in the central nervous system and pituitary of the trout suggests that the peptide may exercise an important role in the regulation of neuroendocrine functions, particularly those related to reproduction. |
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Authors:
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I Anglade; Y Wang; J Jensen; G Tramu; O Kah; J M Conlon |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of comparative neurology Volume: 350 ISSN: 0021-9967 ISO Abbreviation: J. Comp. Neurol. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-03-20 Completed Date: 1995-03-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0406041 Medline TA: J Comp Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 63-74 Citation Subset: IM |
Affiliation:
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Laboratoire de Neurocytochimie Fonctionelle, URA CNRS 339, Talence, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Brain / cytology, metabolism*, ultrastructure Female Galanin Immunohistochemistry Molecular Sequence Data Nerve Fibers / metabolism Neurons / metabolism Neuropeptides / metabolism Oncorhynchus mykiss / metabolism* Peptides / chemistry*, metabolism* Pituitary Gland / cytology, metabolism*, ultrastructure Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 0/Peptides; 88813-36-9/Galanin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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