| Characterization and treatment of resistant hypertension. | |
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MedLine Citation:
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PMID: 19863864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Resistant hypertension is a common medical problem. It carries a significantly increased risk of end-organ damage and cardiovascular events compared with more easily controlled hypertension. Resistant hypertension is most often related to isolated systolic hypertension and is characterized by aldosterone excess and increased intravascular volume. Its diagnosis requires the exclusion of pseudoresistance. The etiology of resistant hypertension is almost always multifactorial. Common reversible contributing factors need to be identified and addressed. Secondary causes of hypertension, such as primary aldosteronism, parenchymal and vascular kidney disease, and obstructive sleep apnea, require investigation and effective treatment if present. Therapy for resistant hypertension should be based on use of rational drug class combinations at optimal doses, with particular attention to adequate diuretic use. The addition of an aldosterone antagonist may further improve blood pressure control. |
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Authors:
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Roberto Pisoni; Mustafa I Ahmed; David A Calhoun |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current cardiology reports Volume: 11 ISSN: 1534-3170 ISO Abbreviation: Curr Cardiol Rep Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-29 Completed Date: 2010-03-04 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 100888969 Medline TA: Curr Cardiol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 407-13 Citation Subset: IM |
Affiliation:
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Vascular Biology and Hypertension Program, University of Alabama at Birmingham, 115 Community Health Services Building, 933 19th Street South, Birmingham, AL 35294, USA. pisoni@uab.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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complications Antihypertensive Agents / therapeutic use* Blood Pressure Drug Resistance Humans Hyperaldosteronism / complications Hypertension / drug therapy*, epidemiology, etiology Kidney Failure, Chronic / complications Life Style Obesity / complications Pheochromocytoma / complications Pituitary ACTH Hypersecretion / complications Prevalence Prognosis Renal Artery Obstruction / complications Risk Factors Sleep Apnea, Obstructive / complications Treatment Failure United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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T32 HL007457-29/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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