Document Detail

Characterization and treatment of resistant hypertension.
MedLine Citation:
PMID:  19863864     Owner:  NLM     Status:  MEDLINE    
Resistant hypertension is a common medical problem. It carries a significantly increased risk of end-organ damage and cardiovascular events compared with more easily controlled hypertension. Resistant hypertension is most often related to isolated systolic hypertension and is characterized by aldosterone excess and increased intravascular volume. Its diagnosis requires the exclusion of pseudoresistance. The etiology of resistant hypertension is almost always multifactorial. Common reversible contributing factors need to be identified and addressed. Secondary causes of hypertension, such as primary aldosteronism, parenchymal and vascular kidney disease, and obstructive sleep apnea, require investigation and effective treatment if present. Therapy for resistant hypertension should be based on use of rational drug class combinations at optimal doses, with particular attention to adequate diuretic use. The addition of an aldosterone antagonist may further improve blood pressure control.
Roberto Pisoni; Mustafa I Ahmed; David A Calhoun
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  11     ISSN:  1534-3170     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-29     Completed Date:  2010-03-04     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  407-13     Citation Subset:  IM    
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MeSH Terms
Adrenal Gland Neoplasms / complications
Antihypertensive Agents / therapeutic use*
Blood Pressure
Drug Resistance
Hyperaldosteronism / complications
Hypertension / drug therapy*,  epidemiology,  etiology
Kidney Failure, Chronic / complications
Life Style
Obesity / complications
Pheochromocytoma / complications
Pituitary ACTH Hypersecretion / complications
Renal Artery Obstruction / complications
Risk Factors
Sleep Apnea, Obstructive / complications
Treatment Failure
United States / epidemiology
Grant Support
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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