| Characterization of total occlusions with intracoronary ultrasound: the importance of the duration of occlusion. | |
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MedLine Citation:
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PMID: 11146677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the impact of the occlusion duration on the characteristics of coronary occlusive plaques. BACKGROUND: The percutaneous recanalization of chronic total coronary occlusions is a technically demanding and yet often unsuccessful procedure due to unfavorable morphological changes described by histology but not well defined in vivo. METHODS: Thirty-five consecutive total occlusions of > or = 1 month duration in previously untreated native coronary arteries were studied using intracoronary ultrasound following dilatation with a 1.5 mm balloon. Plaque characteristics of lesions with an occlusive duration of > or = 3 months (old occlusions) and those of < 3 months (recent occlusions) were then compared. The ultrasound cross-section where there was maximal plaque accumulation at the site of occlusion was analyzed for its qualitative and quantitative characteristics. The lesion remodeling index was defined as the vessel area at occlusion divided by the vessel area at a proximal reference. RESULTS: The old occlusion group comprised 11 lesions whereas 16 lesions were found in the recent occlusion group; the occlusion duration was undetermined in the remaining 8 lesions, and the mean occlusion duration was found to be 4.9 +/- 4.3 months, over a range of 1 36 months. The baseline clinical and angiographic characteristics were similar in the 2 groups. The lesion remodeling index was found to be significantly lower in older occlusions than in the more recent occlusions (0.75 +/- 0.14 vs. 1. 06 +/- 0.25; p = 0.007) and the duration of the occlusion also correlated with the length of calcified segment as determined by ultrasound (p = 0.040), and with a smaller angiographic proximal reference diameter (p = 0.043). CONCLUSION: Long-standing occlusions undergo lesion shrinkage and exhibit more extensive calcification. |
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Authors:
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T Nishida; C Di Mario; C Briguori; R Albiero; A Colombo |
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Publication Detail:
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Type: Comment; Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: The Journal of invasive cardiology Volume: 13 ISSN: 1042-3931 ISO Abbreviation: J Invasive Cardiol Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-31 Completed Date: 2001-02-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8917477 Medline TA: J Invasive Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
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EMO Centro Cuore Columbus, Columbus Clinic and Catheterization Laboratory, San Raffaele Hospital, Via Buonarroti 48, 20145, Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Chronic Disease Coronary Angiography Coronary Disease / radiography, ultrasonography* Coronary Vessels / ultrasonography* Female Humans Male Middle Aged Prognosis Retrospective Studies Severity of Illness Index Time Factors Ultrasonography, Interventional* |
| Comments/Corrections | |
Comment On:
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J Invasive Cardiol. 2001 Jan;13(1):1-8
[PMID:
11146677
]
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Comment In:
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J Invasive Cardiol. 2001 Jan;13(1):1-8
[PMID:
11146677
]
J Invasive Cardiol. 2001 Jan;13(1):9-11 [PMID: 11146678 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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