Document Detail


Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7.
MedLine Citation:
PMID:  10995570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Full-length coding sequences of two novel human cadherin cDNAs were obtained by sequence analysis of several EST clones and 5' and 3' rapid amplification of cDNA ends (RACE) products. Exons for a third cDNA sequence were identified in a public-domain human genomic sequence, and the coding sequence was completed by 3' RACE. One of the sequences (CDH7L1, HGMW-approved gene symbol CDH7) is so similar to chicken cadherin-7 gene that we consider it to be the human orthologue. In contrast, the published partial sequence of human cadherin-7 is identical to our second cadherin sequence (CDH7L2), for which we propose CDH19 as the new name. The third sequence (CDH7L3, HGMW-approved gene symbol CDH20) is almost identical to the mouse "cadherin-7" cDNA. According to phylogenetic analysis, this mouse cadherin-7 and its here presented human homologue are most likely the orthologues of Xenopus F-cadherin. These novel human genes, CDH7, CDH19, and CDH20, are localized on chromosome 18q22-q23, distal of both the gene CDH2 (18q11) encoding N-cadherin and the locus of the six desmosomal cadherin genes (18q12). Based on genetic linkage maps, this genomic region is close to the region to which Paget's disease was linked. Interestingly, the expression patterns of these three closely related cadherins are strikingly different.
Authors:
P Kools; G Van Imschoot; F van Roy
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Genomics     Volume:  68     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-11-16     Completed Date:  2000-11-16     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-95     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Affiliation:
Molecular Cell Biology Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology (VIB), University of Ghent, Ledeganckstraat 35, Ghent, B-9000, Belgium.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF217289;  AJ007607;  AJ007611
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Cadherins / genetics*
Chickens / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 18*
DNA Primers
Exons
Expressed Sequence Tags
Humans
Introns
Male
Mice
Molecular Sequence Data
Multigene Family*
Phylogeny
Sequence Alignment
Sequence Homology, Amino Acid
Chemical
Reg. No./Substance:
0/CDH19 protein, human; 0/CDH20 protein, human; 0/CDH7 protein, human; 0/Cadherins; 0/Cdh20 protein, mouse; 0/DNA Primers

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