| Characterization of three VNTR systems at D21S112. | |
MedLine Citation:
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PMID: 1339394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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D21S112 is a highly polymorphic marker on the long arm of chromosome 21. Our analysis of this locus indicated the presence of three VNTR systems. We estimated the heterozygosity of each system and sequenced one of the repetitive regions. Utilizing PCR, we demonstrated that the sequenced VNTR is responsible for the system with the highest level of heterozygosity. Combining data from the three systems makes D21S112 one of the most informative loci on the chromosome. |
Authors:
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N Takaesu; S Newfeld; T Hassold |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Genomics Volume: 14 ISSN: 0888-7543 ISO Abbreviation: Genomics Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1992-12-17 Completed Date: 1992-12-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8800135 Medline TA: Genomics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 816-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia 30322. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
GENBANK/L01059; L01060; L01061; M93196; M93197; M93198; M93199; M93200; M93201; M95607 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Blotting, Southern Chromosome Mapping Chromosomes, Human, Pair 21* DNA Genetic Markers Humans Molecular Sequence Data Polymorphism, Genetic* Repetitive Sequences, Nucleic Acid* Restriction Mapping |
| Grant Support | |
ID/Acronym/Agency:
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N01-HD 92707/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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