Document Detail


Characterization of three VNTR systems at D21S112.
MedLine Citation:
PMID:  1339394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
D21S112 is a highly polymorphic marker on the long arm of chromosome 21. Our analysis of this locus indicated the presence of three VNTR systems. We estimated the heterozygosity of each system and sequenced one of the repetitive regions. Utilizing PCR, we demonstrated that the sequenced VNTR is responsible for the system with the highest level of heterozygosity. Combining data from the three systems makes D21S112 one of the most informative loci on the chromosome.
Authors:
N Takaesu; S Newfeld; T Hassold
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  14     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-17     Completed Date:  1992-12-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  816-7     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia 30322.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/L01059;  L01060;  L01061;  M93196;  M93197;  M93198;  M93199;  M93200;  M93201;  M95607
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Blotting, Southern
Chromosome Mapping
Chromosomes, Human, Pair 21*
DNA
Genetic Markers
Humans
Molecular Sequence Data
Polymorphism, Genetic*
Repetitive Sequences, Nucleic Acid*
Restriction Mapping
Grant Support
ID/Acronym/Agency:
N01-HD 92707/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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