Document Detail

Characterization of ternary phase diagrams by means of thermal and rheological analyses.
MedLine Citation:
PMID:  23057598     Owner:  NLM     Status:  Publisher    
Context: Mixtures made of oil, water and surfactants give rise to a wide range of structure with different characteristics and phase manifestations. Objective: Aim of this paper is to build up and understand the phase diagram of a model ternary system (Water, Polysorbate 80 and isopropyl myristate) by the use of common techniques such as thermal analysis and rheology, in comparison with visual assessment and polarized light microscopy. Methods: Different ternary systems were prepared and analyzed by means of DSC and rheology in order to highlight the state of water (free, interphasal, bound water) and the samples structural characteristics. Results: The resultant phase diagram is divided into four different zones. Bound water zone is predominant at elevated surfactant/oil ratios, while as the surfactant/oil ratio decreases, DSC reveals the presence of free water. Interphasal water prevails at intermediate water and surfactant content which corresponds with gels systems. Mechanical spectra allow to discern between cubic (true gel) and lamellar mesophases (weak gel), while flow curves allow to distinguish among microemulsions, emulsions or lamellar mesophases. Discussion: A deeper characterization of a model ternary phase diagram is possible, with respect to the simple visual inspection, by the use of thermal analysis and rheology. The state of water molecules and the viscoelastic characteristics of the system allow to obtain important structural considerations. Conclusions: In conclusion, the knowledge of the state of water and of the viscoelastic characteristics of the systems allow a deeper understanding of the structural features of the ternary phase diagram.
Giulia Bonacucina; Marco Cespi; Giovanna Mencarelli; Giovanni F Palmieri
Related Documents :
19693358 - Cell encapsules with tunable transport and mechanical properties.
24169538 - Energetic behavior of the pure silica itq-12 (itw) zeolite under high pressure water in...
17288418 - Classification of water molecules in protein binding sites.
20704188 - Free energy, entropy, and enthalpy of a water molecule in various protein environments.
10735318 - Influence of ph and pka values on electrophoretic behaviour of quinolones in aqueous an...
20866908 - Flow characteristics and exchange in complex biological systems as observed by pulsed-f...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  -     ISSN:  1520-5762     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Camerino, School of Pharmacy , via S. Agostino 1, 62032 Camerino , Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Intense focused ultrasound tightening for the treatment of infraorbital laxity.
Next Document:  Validation of Karolinska Exhaustion Scale: psychometric properties of a measure of exhaustion syndro...