Document Detail


Characterization of a synaptic antigen of interest in neuropsychiatric illness.
MedLine Citation:
PMID:  1737076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monoclonal antibodies exhibiting relative differences in binding to brain homogenates from diseased versus control brains may be useful probes into the molecular pathology of neuropsychiatric illness. To be of value, the antibodies must be useful in characterization of the antigens putatively involved in the illness. An antibody called EP10 showed some differences in binding to homogenates from a small sample of schizophrenia brains compared with controls. In the present study, the antigen for this antibody was characterized in control brains using quantitative, immunocytochemical, and biochemical techniques. The antigen is a 38,000 dalton synaptic vesicle protein, which is identical to synaptophysin by immunological criteria. However, the EP10 epitope is of interest, as this binding site does not appear to be present in rat or bovine synaptophysin. Brain regional studies using EP10 indicate that the antigen may be present in only a subset of synaptic terminals. Further studies are required to fully characterize the epitope, and to determine the significance of the earlier findings related to schizophrenia.
Authors:
W G Honer; C A Kaufmann; P Davies
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  31     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-17     Completed Date:  1992-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-58     Citation Subset:  IM    
Affiliation:
Department of Genetics, New York State Psychiatric Institute, NY.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / analysis*
Antigens / analysis*
Brain / immunology
Brain Chemistry
Cattle
Culture Techniques
Electrophoresis
Female
Humans
Immunoblotting
Immunoenzyme Techniques
Male
Mental Disorders / immunology*
Nervous System Diseases / immunology*
Precipitin Tests
Protein Binding
Rats
Synaptic Vesicles / immunology*
Synaptophysin
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens; 0/Synaptophysin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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