| Characterization of subclonal cell lines showing high motility derived from an undifferentiated human endometrial cancer cell line. | |
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MedLine Citation:
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PMID: 10545749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the relationship between the morphology and the motility of cancer cells, we studied the difference between human endometrial undifferentiated cancer cell lines with different motilities, using light and electron microscopy, immunocytochemistry and RT-PCR. In a transplanted tumor of a cell line with high motility, many connective tissues and microvessels were observed and there were few intercellular spaces, which were ultrastructurally full of extracellular matrix. In the high-motility cell line only cytokeratin 19 was observed, and the level of cytokeratin 19 mRNA was elevated. Thus, motility is suggested to be related to the induction of connective tissues and cytoskeleton. |
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Authors:
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M Koizumi; E Ito; S Yamashita; T Baba; I Yamanaka; T Suzuki; R Kudo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 48 ISSN: 0378-7346 ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-12-17 Completed Date: 1999-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 206-10 Citation Subset: IM |
Affiliation:
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Department of Gynecology and Obstetrics, Sapporo Medical University, School of Medicine, Sapporo, Japan. koizumim@sapmed.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Movement* Endometrial Neoplasms / chemistry, pathology* Female Humans Immunohistochemistry Keratins / analysis, genetics Mice Mice, Inbred BALB C Mice, Nude Microscopy, Confocal Microscopy, Electron Neoplasm Transplantation RNA, Messenger / analysis Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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