Document Detail


Characterization of subclonal cell lines showing high motility derived from an undifferentiated human endometrial cancer cell line.
MedLine Citation:
PMID:  10545749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine the relationship between the morphology and the motility of cancer cells, we studied the difference between human endometrial undifferentiated cancer cell lines with different motilities, using light and electron microscopy, immunocytochemistry and RT-PCR. In a transplanted tumor of a cell line with high motility, many connective tissues and microvessels were observed and there were few intercellular spaces, which were ultrastructurally full of extracellular matrix. In the high-motility cell line only cytokeratin 19 was observed, and the level of cytokeratin 19 mRNA was elevated. Thus, motility is suggested to be related to the induction of connective tissues and cytoskeleton.
Authors:
M Koizumi; E Ito; S Yamashita; T Baba; I Yamanaka; T Suzuki; R Kudo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  48     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1999  
Date Detail:
Created Date:  1999-12-17     Completed Date:  1999-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  206-10     Citation Subset:  IM    
Affiliation:
Department of Gynecology and Obstetrics, Sapporo Medical University, School of Medicine, Sapporo, Japan. koizumim@sapmed.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement*
Endometrial Neoplasms / chemistry,  pathology*
Female
Humans
Immunohistochemistry
Keratins / analysis,  genetics
Mice
Mice, Inbred BALB C
Mice, Nude
Microscopy, Confocal
Microscopy, Electron
Neoplasm Transplantation
RNA, Messenger / analysis
Reverse Transcriptase Polymerase Chain Reaction
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/RNA, Messenger; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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