Document Detail

Characterization of the strain of adenovirus type 7 carrying the defective monkey cell-adapting component.
MedLine Citation:
PMID:  4316236     Owner:  NLM     Status:  MEDLINE    
The strain of adenovirus type 7 carrying the defective monkey cell-adapting component (MAC) has been further characterized. MAC is more sensitive to inactivation by ultraviolet light than the associated adenovirus, which, in turn, is more rapidly inactivated than complete simian virus 40 (SV40). The 37% dose was 16 sec for MAC, 60 sec for adenovirus, and 84 sec for SV40. Filtration through membranes revealed that both MAC and adenovirus were retained by 100-mmu filters. MAC equilibrated in cesium chloride at the same buoyant density as the complete adenovirions (1.34 g/ml). Deoxyribonucleic acid extracted from green monkey kidney cells infected with MAC-adenovirus 7 did not hybridize in vitro with SV40 complementary ribonucleic acid. The two components (MAC and adenovirus) of the virus population possess such similar biophysical properties that their separation has not yet been achieved. Evidence to date indicates that MAC is probably not derived from SV40.
J S Butel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of virology     Volume:  1     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1967 Oct 
Date Detail:
Created Date:  1970-08-07     Completed Date:  1970-08-07     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  876-82     Citation Subset:  IM    
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MeSH Terms
Adenoviridae / classification*,  radiation effects
Centrifugation, Density Gradient
Culture Techniques*
Cytopathogenic Effect, Viral
DNA, Viral / metabolism
Defective Viruses
Helper Viruses
Hybridization, Genetic
Simian virus 40 / radiation effects
Ultraviolet Rays
Virus Replication
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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