| Characterization of small (≤10 mm) focal liver lesions: value of respiratory-triggered echo-planar diffusion-weighted MR imaging. | |
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MedLine Citation:
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PMID: 19501995 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To evaluate respiratory-triggered diffusion-weighted MR imaging (DWI) in the characterization of small (≤10 mm) focal liver lesions (FLL). MATERIALS AND METHODS: A total of 185 FLL (76 metastases, 11 HCCs, 71 cysts, 18 hemangiomas, 6 focal nodular hyperplasias, 3 adenomas) were retrospectively analyzed in 77 patients. DWI was performed at 1.5 T using a respiratory-triggered single-shot echo-planar imaging (SSEPI) sequence (b values: 50, 300, 600 s/mm(2)). Diffusion-weighted images were evaluated by two independent observers and apparent diffusion coefficient (ADC) values were determined. Reference standard of diagnosis was obtained by two other radiologists correlating DWI with histopathologic findings, standard MR sequences and imaging follow-up. Receiver operating characteristic curve analysis was performed to evaluate the utility of ADC values for the diagnosis of malignancy. RESULTS: Accuracy for characterizing FLL was 93.0% for reader 1 and 91.9% for reader 2. Interobserver agreement was excellent between both readers (κ=0.88). Sensitivity and specificity for diagnosing malignancy were 90.8% and 89.9% using a threshold ADC of 1.41×10(-3) mm(2)/s. CONCLUSION: DWI using the respiratory-triggered SSEPI sequence can help to characterize FLL, even when the diameter of lesions is 10mm or less. |
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Authors:
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Konstantin Holzapfel; Melanie Bruegel; Matthias Eiber; Carl Ganter; Tibor Schuster; Petra Heinrich; Ernst J Rummeny; Jochen Gaa |
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Publication Detail:
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Type: Journal Article Date: 2009-06-06 |
Journal Detail:
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Title: European journal of radiology Volume: 76 ISSN: 1872-7727 ISO Abbreviation: Eur J Radiol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 89-95 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Radiology, Klinikum rechts der Isar, Technische Universitaet Muenchen (TUM), Munich, Germany. holzapfel@roe.med.tum.de |
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