Document Detail

Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in mice.
MedLine Citation:
PMID:  19904815     Owner:  NLM     Status:  In-Data-Review    
Volatile organic compounds (VOCs) are considered the main cause of sick building syndrome and they are likely to irritate the skin, eyes, and mucous membrane; however, the toxic threshold and the mechanisms of cutaneous reaction induced by long-time VOC exposure have not been clarified. In the present study, we investigated the effect of repeated painting of VOCs onto mouse skin. Various concentrations of toluene, xylene, and formaldehyde (FA) were applied once a week for 5 weeks. While FA solution (2-10%) induced remarkable ear swelling and caused evident infiltration of inflammatory cells, high concentrations of toluene and xylene (50 or 100%) evoked mild ear swelling and marginal inflammatory cell invasion. In addition, FA exposure markedly increased the expression of interleukin-4 (IL-4), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and transient receptor potential vanilloid-1 (TRPV-1) mRNAs in the ears and IL-4 and NT-3 mRNAs in the cervical lymph nodes. Furthermore, capsazepine, a TRPV-1 antagonist, significantly suppressed ear swelling caused by repeated painting of 5% FA. These findings demonstrate that FA has more potent irritancy against skin than toluene or xylene and suggest that the Th2 response, neurotrophins and TRPV-1 play important roles in FA-induced skin inflammation. © 2009 Wiley Periodicals, Inc. Environ Toxicol, 2011.
Asaka Saito; Hiroyuki Tanaka; Haruki Usuda; Tomonori Shibata; Sayaka Higashi; Hirotaka Yamashita; Naoki Inagaki; Hiroichi Nagai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental toxicology     Volume:  26     ISSN:  1522-7278     ISO Abbreviation:  Environ. Toxicol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100885357     Medline TA:  Environ Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  224-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Wiley Periodicals, Inc.
Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan.
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