| Characterization of secretory IgA responses in mice infected with Cryptosporidium parvum. | |
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MedLine Citation:
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PMID: 9184934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mice inoculated at 5, 21 and 28 days of age with 10(6) or 10(7) Cryptosporidium parvum oocysts became infected but did not exhibit any clinical signs of disease. Specific IgA antibodies were detected in faecal extracts from all infected mice by an indirect immunofluorescent assay. These antibodies first appeared between 11 and 37 days post-infection (dpi) and persisted until the end of the experiment at 55 dpl. They appeared earlier in older mice than in newborn mice. Reduction and resolution of oocyst shedding was not directly related, however, to IgA antibody levels in infected mice. Reactive C. parvum antigens were identified by immunoblotting techniques using faecal and serum samples from infected mice. IgA copro-antibodies reacted specifically with two antigens of 26 and 33 kDa, which were also identified by IgG antibodies in mouse serum. The role of these antibodies in the resolution of infections and the subsequent protection against challenge is unknown. |
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Authors:
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R Tarazona; N C Lally; M Dominguez-Carmona; D A Blewett |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal for parasitology Volume: 27 ISSN: 0020-7519 ISO Abbreviation: Int. J. Parasitol. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-10-02 Completed Date: 1997-10-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0314024 Medline TA: Int J Parasitol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 417-23 Citation Subset: IM |
Affiliation:
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Departamento de medicina Preventiva, Facultad de Medicina, Universidad Complutense, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Protozoan / immunology* Cattle Cryptosporidiosis / immunology* Cryptosporidium parvum / immunology* Disease Models, Animal Feces / parasitology Immunoglobulin A, Secretory / immunology* Mice |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Protozoan; 0/Immunoglobulin A, Secretory |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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