| Characterization of scattered neuroendocrine cells in ductal carcinoma of the pancreas. | |
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MedLine Citation:
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PMID: 12142735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Scattered neuroendocrine cells, identified by chromogranin A (CGA) immunoreactivity, have been observed in pancreatic ductal carcinomas, accounting for <1% of the entire tumor cell population. AIMS AND METHODOLOGY: To determine the characteristics of scattered CGA-positive cells, the differentiation markers for the cells of epithelial origin (cytokeratin [CK] 19) and of endocrine origin (CGA) were evaluated by immunohistochemistry and double immunofluorescent staining. RESULTS: Some of these CGA-positive cells scattered amid malignant cells also express CK19, suggesting that they are neuroendocrine-differentiated carcinoma cells. However, scattered CGA-positive cells, mostly located at the basal and/or outer portions of malignant ducts, did not express CK19, indicating that these cells are probably entrapped endocrine cells. Examination of the lymph node metastases for CGA in 19 patients showed no staining with CGA, suggesting that neuroendocrine-differentiated tumor cells have a different behavior. CONCLUSION: The current study did not show any clinical significance of these scattered neuroendocrine cells. |
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Authors:
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Ekmel Tezel; Tetsuro Nagasaka; Gaye Tezel; Akimasa Nakao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreas Volume: 25 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-26 Completed Date: 2002-08-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: 136-41 Citation Subset: IM |
Affiliation:
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Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan. ekmeltezel@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Pancreatic Ductal / metabolism, mortality, pathology* Chromogranin A Chromogranins / analysis Female Humans Immunohistochemistry Male Middle Aged Neurosecretory Systems / chemistry, pathology* Pancreatic Neoplasms / metabolism, mortality, pathology* Survival Analysis Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Chromogranin A; 0/Chromogranins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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