| Characterization and reproducibility of forearm arterial flow during reactive hyperemia. | |
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MedLine Citation:
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PMID: 20410556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peripheral arterial flow has been assessed for a variety of indications including characterization of endothelial function during reactive hyperemia. However, quantification of this blood flow as a surrogate remains an imperfect reflection of endothelial function. We sought to better characterize hyperemic reaction to (1) elucidate the influence of the endothelial function and (2) assess the reproducibility of our modeling over time. Sixteen normal subjects underwent simultaneous forearm reactive hyperemia testing with a near-infrared system at baseline, baseline +24 h and baseline +27 h. Baseline flow was measured to 3.6 +/- 0.2 ml dl(-1) min(-1), and was highly reproducible 24 and 27 h later. With reactive hyperemia, the blood flow increased to 20.5 +/- 4.6 ml dl(-1) min(-1). Arterial blood flow curves during reactive hyperemia displayed a bimodal pattern, with the second peak occurring 59.1 +/- 10.6 s after the onset of hyperemia. We believe that this latest peak represents the contribution of endothelial factors to the hyperemic reaction. Modeling of hyperemic curves led to the introduction of a reproducible new parameter (etafactor) that reflects the normalized contribution of this second peak. In conclusion, forearm arterial flow during reactive hyperemia revealed a bimodal distribution where functional interpretation allowed distinction of the two components. Basal flow measurements and results of this modeling were reproducible 24 and 27 h later. |
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Authors:
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Nina Olamaei; Jocelyn Dupuis; Quam Ngo; Vincent Finnerty; Thanh-Thuy Vo Thang; Sébastien Authier; Paul Khairy; François Harel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-22 |
Journal Detail:
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Title: Physiological measurement Volume: 31 ISSN: 1361-6579 ISO Abbreviation: Physiol Meas Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306921 Medline TA: Physiol Meas Country: England |
Other Details:
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Languages: eng Pagination: 763-73 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteries / physiopathology* Female Forearm / blood supply* Humans Hyperemia / complications, diagnosis, physiopathology* Ischemia / complications Male Plethysmography Regional Blood Flow* Reproducibility of Results Spectrophotometry, Infrared Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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