Document Detail

Characterization of the rat myometrial contractile response to neuropeptide Y.
MedLine Citation:
PMID:  8771529     Owner:  NLM     Status:  MEDLINE    
The in vitro contractile effect of neuropeptide Y (NPY) on rat myometrial strips was for the first time demonstrated and characterised, and the EC50 value estimated to be 267 +/- 87 nM. This effect is presumably mediated by the NPY1 receptor being responsible for postsynaptic effects throughout the peripherial nervous system, thus indicating a direct uterotonic effect of NPY. Further, the effect was demonstrated to the dependent on extracellular Ca2+. Short-term exposures to NPY markedly desensitized the tissue affecting subsequent responses to NPY as well as to oxytocin (OT). This desensitization was time and concentration-dependent, but lasted less than three hours. However, long-term infusions of NPY for 5 days increased to response to both NPY and OT. Long-term infusions of OT caused a marked decrease of the NPY response, and it is concluded that common pathways for up and down regulation of the myometrial responsiveness to several peptide hormones may exist.
A Atke; J S Henriksen; H S Jacobsen; H Vilhardt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of receptor and signal transduction research     Volume:  16     ISSN:  1079-9893     ISO Abbreviation:  J. Recept. Signal Transduct. Res.     Publication Date:    1996 Jan-Mar
Date Detail:
Created Date:  1997-01-21     Completed Date:  1997-01-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9509432     Medline TA:  J Recept Signal Transduct Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  25-38     Citation Subset:  IM    
Department of Medical Physiology, University of Copenhagen, Denmark.
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MeSH Terms
Calcium / metabolism
Dose-Response Relationship, Drug
Muscle Contraction / drug effects*
Myometrium / physiology*
Neuropeptide Y / administration & dosage,  analogs & derivatives,  metabolism,  pharmacology*
Oxytocin / pharmacology
Rats, Wistar
Receptors, Neuropeptide Y / metabolism
Verapamil / pharmacology
Reg. No./Substance:
0/Neuropeptide Y; 0/Receptors, Neuropeptide Y; 125580-28-1/neuropeptide Y, Leu(31)-Pro(34)-; 50-56-6/Oxytocin; 52-53-9/Verapamil; 7440-70-2/Calcium

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