| Characterization and quantification of vortex flow in the human left ventricle by contrast echocardiography using vector particle image velocimetry. | |
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MedLine Citation:
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PMID: 19356506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aims of this study were to: 1) assess the feasibility of left ventricular (LV) vortex flow analysis using contrast echocardiography (CE); and 2) characterize and quantify LV vortex flow in normal subjects and patients with LV systolic dysfunction. BACKGROUND: Vortices that form during LV filling have specific geometry and anatomical locations that are critical determinants of directed blood flow during ejection. Therefore, it is clinically relevant to assess the vortex flow patterns to better understand the LV function. METHODS: Twenty-five patients (10 normal and 15 patients with abnormal LV systolic function) underwent CE with intravenous contrast agent, Definity (Bristol-Myers Squibb Medical Imaging, Inc., North Billerica, Massachusetts). The velocity vector and vorticity were estimated by particle image velocimetry. Average vortex parameters including vortex depth, transverse position, length, width, and sphericity index were measured. Vortex pulsatility parameters including relative strength, vortex relative strength, and vortex pulsation correlation were also estimated. RESULTS: Vortex depth and vortex length were significantly lower in the abnormal LV function group (0.443 +/- 0.04 vs. 0.482 +/- 0.06, p < 0.05; 0.366 +/- 0.06 vs. 0.467 +/- 0.05, p < 0.01, respectively). Vortex width was greater (0.209 +/- 0.05 vs. 0.128 +/- 0.06, p < 0.01) and sphericity index was lower (1.86 +/- 0.5 vs. 3.66 +/- 0.6, p < 0.001) in the abnormal LV function group. Relative strength (1.13 +/- 0.4 vs. 2.10 +/- 0.8, p < 0.001), vortex relative strength (0.57 +/- 0.2 vs. 1.19 +/- 0.5, p < 0.001), and vortex pulsation correlation (0.63 +/- 0.2 vs. 1.31 +/- 0.5, p < 0.001) were significantly lower in the abnormal LV function group. CONCLUSIONS: It was feasible to quantify LV vorticity arrangement by CE using particle image velocimetry in normal subjects and those with LV systolic dysfunction, and the vorticity imaging by CE may serve as a novel approach to depict vortex, the principal quantity to assess the flow structure. |
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Authors:
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Geu-Ru Hong; Gianni Pedrizzetti; Giovanni Tonti; Peng Li; Zhao Wei; Jin Kyung Kim; Abinav Baweja; Shizhen Liu; Namsik Chung; Helene Houle; Jagat Narula; Mani A Vannan |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2008-11-18 |
Journal Detail:
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Title: JACC. Cardiovascular imaging Volume: 1 ISSN: 1876-7591 ISO Abbreviation: JACC Cardiovasc Imaging Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2009-04-09 Completed Date: 2009-04-23 Revised Date: 2009-05-21 |
Medline Journal Info:
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Nlm Unique ID: 101467978 Medline TA: JACC Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 705-17 Citation Subset: IM |
Affiliation:
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Ohio State University, Columbus, Ohio 43210, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Contrast Media / diagnostic use* Echocardiography, Doppler, Color / methods* Feasibility Studies Female Fluorocarbons / diagnostic use* Fourier Analysis Humans Image Interpretation, Computer-Assisted Laser-Doppler Flowmetry* Male Middle Aged Pilot Projects Predictive Value of Tests Pulsatile Flow Stroke Volume Ventricular Dysfunction, Left / physiopathology, ultrasonography* Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Definity; 0/Fluorocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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