Document Detail


Characterization of the putative maltose transporters encoded by YDL247w and YJR160c.
MedLine Citation:
PMID:  12210897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The maltose permease family of Saccharomyces cerevisiae comprises five proteins, three of which are characterized, MAL31, MAL61 and AGT1 and two putative permeases, YDL247w (MPH2) and YJR160c (MPH3). The two uncharacterized permeases share 100% identity and have 75% identity with MAL31 and MAL61 and 55% identity with AGT1. Characterization of the genes YDL247w and YJR160c confirmed that they encode alpha-glucoside permeases capable of transporting maltose, maltotriose, alpha-methylglucoside and turanose. Analysis of the promoter regions identified regulatory elements, binding sites for the transcriptional activator, Malx3p and the inhibitory protein, Mig1p. Further analysis of the flanking sequences located blocks of identity covering five open reading frames, indicating that this region was involved in chromosomal block duplication. The members of the maltose permease family are proteins that have strongly overlapping but nevertheless distinct functions, which is a selective advantage for yeast, as it reflects successful adaptation to the variety of environmental conditions to which the yeast cells are exposed; such adaptability is very important in an industrial context.
Authors:
Rachel E Day; Vincent J Higgins; Peter J Rogers; Ian W Dawes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Yeast (Chichester, England)     Volume:  19     ISSN:  0749-503X     ISO Abbreviation:  Yeast     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-04     Completed Date:  2002-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607637     Medline TA:  Yeast     Country:  England    
Other Details:
Languages:  eng     Pagination:  1015-27     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Ltd.
Affiliation:
Clive and Vera Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
DNA, Fungal / genetics
Gene Expression Regulation, Fungal
Genes, Fungal
Glucosides / metabolism
Maltose / metabolism*
Membrane Transport Proteins / chemistry,  genetics*,  metabolism*
Molecular Sequence Data
Monosaccharide Transport Proteins / chemistry,  genetics*,  metabolism
Saccharomyces cerevisiae / genetics*,  growth & development,  metabolism
Saccharomyces cerevisiae Proteins / chemistry,  genetics*,  metabolism*
Sequence Alignment
Sequence Analysis, DNA
Substrate Specificity
Symporters / chemistry,  genetics*,  metabolism
Trisaccharides / metabolism
Chemical
Reg. No./Substance:
0/DNA, Fungal; 0/Glucosides; 0/MPH2 protein, S cerevisiae; 0/MPH3 protein, S cerevisiae; 0/Membrane Transport Proteins; 0/Monosaccharide Transport Proteins; 0/Saccharomyces cerevisiae Proteins; 0/Symporters; 0/Trisaccharides; 0/maltose transport system, S cerevisiae; 1109-28-0/maltotriose; 69-79-4/Maltose; 9055-23-6/maltose permease

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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