Document Detail


Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome.
MedLine Citation:
PMID:  15657466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: There is currently no optimal treatment or effective drug for severe acute respiratory syndrome (SARS), because the immunopathologic mechanism is poorly understood. Objectives: To explore the immune mechanism underlying the pathogenesis of SARS, we studied the expression profile of cytokines/chemokines in the blood and the immunopathology of the lung and lymphoid tissues. METHODS: Fourteen cytokines/chemokines in the blood of 23 patients with SARS were dynamically screened, using a bead-based multiassay system. Reverse transcription-polymerase chain reaction was performed to amplify mRNA. Histopathology of the lung and lymphoid tissues at autopsy was examined, using methods of immunohistochemistry and double immunofluorescence staining. MAIN RESULTS: Interferon-inducible protein-10 (IP-10) was markedly elevated in the blood during the early stage of SARS, and remained at a high level until convalescence. Moreover, IP-10 was highly expressed in both lung and lymphoid tissues, where monocyte-macrophage infiltration and depletion of lymphocytes were observed. The levels of interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 were concomitantly increased in the blood of the patients with superinfection, and the mRNAs for these cytokines were also increased in lung tissues. CONCLUSIONS: Induction of IP-10 is a critical event in the initiation of immune-mediated acute lung injury and lymphocyte apoptosis during the development of SARS. Superinfection after the immune injury is the main cause of death. The prompt elevation of interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 is a sign of superinfection, indicating a high risk of death.
Authors:
Yong Jiang; Jun Xu; Chengzhi Zhou; Zhenguo Wu; Shuqing Zhong; Jinghua Liu; Wei Luo; Tao Chen; Qinghe Qin; Peng Deng
Related Documents :
1355796 - Expression of the cd11/cd18 cell surface adhesion glycoprotein family and mhc class ii ...
8160716 - Southwestern internal medicine conference: sarcoidosis: immunology and clinical managem...
7897226 - Regulatory effects of intrinsic il-10 in igg immune complex-induced lung injury.
20693906 - Recent advances in pulmonary fibrosis: implications for scleroderma.
22091406 - A perspective on the emergence of sialic acids as potent determinants affecting leishma...
21713616 - Leech immunity: from brain to peripheral responses.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-18
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  171     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-08     Completed Date:  2006-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  850-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathophysiology, Southern Medical University, Tonghe, Guangzhou 510515, China. yjiang@fimmu.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Apoptosis / immunology
Chemokine CCL2 / blood
Chemokines / blood*,  genetics
Cytokines / blood*,  genetics
Female
Gene Expression / physiology
Humans
Lung / immunology,  pathology
Lymphocytes / immunology,  pathology
Lymphoid Tissue / pathology
Male
Microscopy, Fluorescence
Middle Aged
Reference Values
Reverse Transcriptase Polymerase Chain Reaction
SARS Virus / immunology
Severe Acute Respiratory Syndrome / diagnosis,  immunology*,  pathology
Superinfection / immunology,  pathology
Chemical
Reg. No./Substance:
0/Chemokine CCL2; 0/Chemokines; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hypocapnia is not a predictor of central sleep apnea in patients with cirrhosis.
Next Document:  Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.