Document Detail

Characterization of portal vein thrombus with the use of contrast-enhanced sonography.
MedLine Citation:
PMID:  16929015     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To select an appropriate treatment regimen, it is essential to accurately characterize the nature of a thrombus. This study prospectively assessed the ability of contrast-enhanced sonography to differentiate between benign and malignant portal vein thrombosis in a population of high-risk patients. METHODS: Fifty-five patients (43 men and 12 women; mean age, 66 years; range, 55-83 years) with thrombi of the portal venous system were examined by power Doppler sonography and contrast-enhanced sonography with the intravenous contrast agent SH U 508A (Levovist; Schering AG, Berlin, Germany). Of the thrombi, 40 were characterized as malignant and 15 as benign. Pulsatile flow in the thrombus on power Doppler sonography and positive enhancement of the thrombus on contrast-enhanced sonography were judged as indications of a malignant thrombus. The sensitivity and specificity of both methods in differentiating the nature of the thrombus were evaluated. RESULTS: The detection of pulsatile flow in a portal vein thrombus as the criterion for diagnosing malignant portal vein thrombus yielded overall sensitivity of 82.5% and specificity of 100%, whereas positive enhancement of the portal vein thrombus itself as a criterion for diagnosing malignancy yielded overall sensitivity and specificity of 100% for each. CONCLUSIONS: Contrast-enhanced sonography can be helpful in discriminating between benign and malignant portal vein thrombi.
Norio Ueno; Harunobu Kawamura; Hirokazu Takahashi; Nobutaka Fujisawa; Masato Yoneda; Hiroyuki Kirikoshi; Takashi Sakaguchi; Satoru Saito; Shinji Togo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  25     ISSN:  0278-4297     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-24     Completed Date:  2006-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1147-52     Citation Subset:  IM    
Division of Endoscopy, Yokohama City University Hospital, 3-9 Fukuura, Yokohama 236-0004, Japan.
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MeSH Terms
Aged, 80 and over
Contrast Media
Diagnosis, Differential
Middle Aged
Polysaccharides / diagnostic use*
Portal Vein*
Prospective Studies
Risk Factors
Sensitivity and Specificity
Thrombosis / ultrasonography*
Reg. No./Substance:
0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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