Document Detail

Characterization of paramagnetic effects of molecular oxygen on blood oxygenation level-dependent-modulated hyperoxic contrast studies of the human brain.
MedLine Citation:
PMID:  21608026     Owner:  NLM     Status:  Publisher    
In hyperoxic contrast studies modulated by the blood oxygenation level-dependent effect, it is often assumed that hyperoxia is a purely intravascular, positive contrast agent in T 2*-weighted images, and the effects that are not due to blood oxygenation level-dependent contrast are small enough to be ignored. In this study, this assumption is re-evaluated and non-blood oxygenation level-dependent effects in T 2*-weighted hyperoxic contrast studies of the human brain were characterized. We observed significant negative signal changes in T 2*-weighted images in the frontal lobes; B(0) maps suggest that this effect was primarily due to increased intravoxel dephasing from increased static field inhomogeneity due to susceptibility changes from oxygen in and around the upper airway. These static field effects were shown to scale with magnetic field strength. Signal changes observed around the brain periphery and in the ventricles suggest the effect of image distortions from oxygen-induced bulk B(0) shifts, along with a possible contribution from decreased T 2* due to oxygen dissolved in the cerebrospinal fluid. Reducing the concentration of inhaled oxygen was shown to mitigate negative contrast of molecular oxygen due to these effects, while still maintaining sufficient blood oxygenation level-dependent contrast to produce accurate measurements of cerebral blood volume. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc.
David T Pilkinton; Santosh R Gaddam; Ravinder Reddy
Related Documents :
21716686 - Free flap blood flow evaluated using two-dimensional laser speckle flowgraphy.
21878946 - Comparative effects of glucose- and mannitol-induced osmolar stress on blood-brain barr...
21570096 - Minimizing intraoperative hemodilution by use of a very low priming volume cardiopulmon...
22148716 - Validation of paper-based assay for rapid blood typing.
6427796 - Perfluorochemical perfusion of the isolated guinea pig heart.
1247926 - The effects of furosemide on remal blood flow and cortical perfusion during methoxyflur...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-23
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  -     ISSN:  1522-2594     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Radiology, Center for Magnetic Resonance and Optical Imaging (CMROI), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surprising evidence of pelvic growth (widening) after skeletal maturity.
Next Document:  B(0) mapping with multi-channel RF coils at high field.