| Characterization of p-aminobenzoic acid transport across the rat intestine. | |
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MedLine Citation:
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PMID: 304877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intestinal absorption of PABA, a member of the vitamin B complex, was characterized in vivo and in vitro in the rat by the segmental intestinal perfusion and everted gut sac technique. Net PABA absorption was directly proportional to substrate concentration, and saturation of absorption did not occur with increasing concentrations of PABA (1 to 50 mM), indicating a nonsaturable process. Jejunal and ileal absorption rates were similar and were not influenced by the presence of glucose or the absence of sodium in the test solution. Similarly, 14C-PABA transport in vitro was nonsaturable and proportional to PABA concentration (0.05, 0.5, 1, 10, and 50 mM). It was not inhibited by ouabain or other PABA analogues such as folic acid and benzoic acid. These studies indicate that PABA, a vitamin B cofactor, is absorbed by a nonsaturable, sodium-independent process, which characterizes passive diffusion and is similar to the absorption of other vitamin B members. |
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Authors:
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C Arvanitakis; M P Longnecker; J Folscroft |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 91 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1978 Mar |
Date Detail:
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Created Date: 1978-04-26 Completed Date: 1978-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 467-72 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminobenzoic Acid
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metabolism* Aminobenzoic Acids / metabolism* Animals Benzoates / pharmacology Folic Acid / pharmacology Glucose / pharmacology Ileum / metabolism* Intestinal Absorption* / drug effects Jejunum / metabolism* Male Ouabain / pharmacology Rats Sodium Chloride / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Aminobenzoic Acids; 0/Benzoates; 150-13-0/4-Aminobenzoic Acid; 50-99-7/Glucose; 59-30-3/Folic Acid; 630-60-4/Ouabain; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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