Document Detail

Characterization of p-aminobenzoic acid transport across the rat intestine.
MedLine Citation:
PMID:  304877     Owner:  NLM     Status:  MEDLINE    
The intestinal absorption of PABA, a member of the vitamin B complex, was characterized in vivo and in vitro in the rat by the segmental intestinal perfusion and everted gut sac technique. Net PABA absorption was directly proportional to substrate concentration, and saturation of absorption did not occur with increasing concentrations of PABA (1 to 50 mM), indicating a nonsaturable process. Jejunal and ileal absorption rates were similar and were not influenced by the presence of glucose or the absence of sodium in the test solution. Similarly, 14C-PABA transport in vitro was nonsaturable and proportional to PABA concentration (0.05, 0.5, 1, 10, and 50 mM). It was not inhibited by ouabain or other PABA analogues such as folic acid and benzoic acid. These studies indicate that PABA, a vitamin B cofactor, is absorbed by a nonsaturable, sodium-independent process, which characterizes passive diffusion and is similar to the absorption of other vitamin B members.
C Arvanitakis; M P Longnecker; J Folscroft
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  91     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-04-26     Completed Date:  1978-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  AIM; IM    
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MeSH Terms
4-Aminobenzoic Acid / metabolism*
Aminobenzoic Acids / metabolism*
Benzoates / pharmacology
Folic Acid / pharmacology
Glucose / pharmacology
Ileum / metabolism*
Intestinal Absorption* / drug effects
Jejunum / metabolism*
Ouabain / pharmacology
Sodium Chloride / pharmacology
Reg. No./Substance:
0/Aminobenzoic Acids; 0/Benzoates; 150-13-0/4-Aminobenzoic Acid; 50-99-7/Glucose; 59-30-3/Folic Acid; 630-60-4/Ouabain; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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