| Characterization and outcome of uveitis in 350 patients with spondyloarthropathies. | |
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MedLine Citation:
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PMID: 16957887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This retrospective study analyzed 350 patients with the diagnosis of spondyloarthropathies (SPA) (207 with ankylosing spondylitis (AS), 80 with undifferentiated spondyloarthropathies (USPA) and 63 with psoriatic arthritis (PsA)) attended at a tertiary referral hospital for a minimum period of 5 years. All the patients presented complete clinical (axial and peripheral involvement, heel enthesopathies, extra-articular manifestations) and radiologic (sacroiliac, lumbar, dorsal and cervical spine) evaluation. HLA-B27 and respective alleles were searched. These data were compared with the occurrence of uveitis during the follow-up of the SPA patients. Thirty AS patients (14.5%) presented 55 episodes of acute anterior uveitis; there was statistical association between uveitis and juvenile-onset AS (P = 0.0094) and achillean (P = 0.0003) and plantar (P = 0.0067) enthesopathies; one AS patient presented a single episode of posterior uveitis, associated to tuberculosis. Seven USPA patients (8.8%) presented 13 episodes of acute anterior uveitis; it was not observed statistical association with any variable; one patient presented a single episode of posterior uveitis, associated to toxoplasmosis. Five HLA-B27 positive PsA patients (8%) presented 13 episodes of acute anterior uveitis. All the 26 positive HLA-B27 SPA patients with anterior uveitis tested for the HLA-B27 alleles were HLA-B*2705. No patient presented ophthalmologic severe sequelae of the anterior uveitis. Concluding, anterior uveitis was associated to the juvenile onset of the disease and to the enthesophatic involvement of the lower limbs in AS patients. The HLA-B*2705 allele was predominant in the anterior uveitis patients, whilst posterior uveitis was rare and associated to infectious disease. |
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Authors:
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Percival D Sampaio-Barros; Roseneide A Conde; Rubens Bonfiglioli; Manoel B Bértolo; Adil M Samara |
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Publication Detail:
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Type: Journal Article Date: 2006-09-07 |
Journal Detail:
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Title: Rheumatology international Volume: 26 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-25 Completed Date: 2007-02-28 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 1143-6 Citation Subset: IM |
Affiliation:
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Unit of Rheumatology, Department of Internal Medicine, State University of Campinas, Faculty of Medical Sciences FCM/UNICAMP, Barão Geraldo, CEP 13081-970 Campinas, SP, Brazil. psbarros@fcm.unicamp.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alleles Arthritis, Psoriatic / complications* Female HLA-B Antigens / genetics* HLA-B27 Antigen Humans Male Spondylarthropathies / complications* Spondylitis, Ankylosing / complications* Treatment Outcome Uveitis / diagnosis*, genetics*, therapy |
| Chemical | |
Reg. No./Substance:
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0/HLA-B 2705 antigen; 0/HLA-B Antigens; 0/HLA-B27 Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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