Document Detail


Characterization of a novel subset of cardiac cells and their progenitors in the Drosophila embryo.
MedLine Citation:
PMID:  11044409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Drosophila heart is a simple organ composed of two major cell types: cardioblasts, which form the simple contractile tube of the heart, and pericardial cells, which flank the cardioblasts. A complete understanding of Drosophila heart development requires the identification of all cell types that comprise the heart and the elucidation of the cellular and genetic mechanisms that regulate the development of these cells. Here, we report the identification of a new population of heart cells: the Odd skipped-positive pericardial cells (Odd-pericardial cells). We have used descriptive, lineage tracing and genetic assays to clarify the cellular and genetic mechanisms that control the development of Odd-pericardial cells. Odd skipped marks a population of four pericardial cells per hemisegment that are distinct from previously identified heart cells. We demonstrate that within a hemisegment, Odd-pericardial cells develop from three heart progenitors and that these heart progenitors arise in multiple anteroposterior locations within the dorsal mesoderm. Two of these progenitors divide asymmetrically such that each produces a two-cell mixed-lineage clone of one Odd-pericardial cell and one cardioblast. The third progenitor divides symmetrically to produce two Odd-pericardial cells. All remaining cardioblasts in a hemisegment arise from two cardioblast progenitors each of which produces two cardioblasts. Furthermore, we demonstrate that numb and sanpodo mediate the asymmetric divisions of the two mixed-lineage heart progenitors noted above.
Authors:
E J Ward; J B Skeath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  127     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-08     Completed Date:  2001-01-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  4959-69     Citation Subset:  IM    
Affiliation:
Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Carrier Proteins / genetics
Cell Differentiation
DNA-Binding Proteins / genetics,  physiology
Drosophila / embryology*,  genetics,  metabolism
Drosophila Proteins*
Enhancer Elements, Genetic
Genes, Insect
Heart / embryology*
Juvenile Hormones / genetics
Mesoderm / cytology
Microfilament Proteins
Mutation
Myocardium / cytology,  metabolism
Stem Cells / cytology,  metabolism
Transcription Factors / genetics,  physiology
Grant Support
ID/Acronym/Agency:
R01NS36570/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Juvenile Hormones; 0/Microfilament Proteins; 0/Transcription Factors; 0/numb protein, Drosophila; 0/sanpodo protein, Drosophila; 132191-97-0/odd protein, Drosophila

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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