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Characterization of nonalcoholic fatty liver disease unrelated to the metabolic syndrome.
MedLine Citation:
PMID:  21913918     Owner:  NLM     Status:  Publisher    
Eur J Clin Invest 2011 ABSTRACT: Background  Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome (MS). However, not all patients with the MS will develop NAFLD and not all patients with NAFLD have the MS. We sought to investigate the differences between patients with biopsy-proven NAFLD with and without the MS. Methods  A total of 357 consecutive patients with biopsy-proven NAFLD were analysed. Of them, 216 patients had nonalcoholic steatohepatitis (NASH) and 96 a fibrosis score ≥ 2. The MS was defined as ≥ 3 of the ATP III criteria. Results  A total of 214 patients with NAFLD met the criteria for the MS, while the remaining 143 did not. In NAFLD patients with the MS, homeostasis model of insulin resistance (P = 0·03; OR, 1·06; 95% CI, 1·023-1·25 per unit increase) and diabetes (P = 0·01; OR, 1·2; 95% CI, 1·1-2·4) were independent predictors of NASH. In NAFLD patients without the MS, the only variable independently associated with NASH was haemoglobin (P = 0·007; OR, 1·9; 95% CI, 1·4-3·6 per 50 g/L increase). Alanine aminotransferase (P = 0·03; OR, 1·04; 95% CI, 1·006-1·11 per 10 U/L increase) was an independent predictor of fibrosis ≥ 2 in NAFLD patients with the MS, while haemoglobin (P = 0·02; OR, 1·4; 95% CI, 1·2-1·9 per 50 g/L increase) was the only variable significantly associated with fibrosis ≥ 2 in NAFLD patients without the MS. Conclusions  Increased haemoglobin in NAFLD subjects without MS should be considered in the selection of cases for histological assessment.
Yusuf Yilmaz; Ebubekir Senates; Talat Ayyildiz; Yasar Colak; Ilyas Tuncer; Ayse Oya Kurdas Ovunc; Enver Dolar; Cem Kalayci
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-18
Journal Detail:
Title:  European journal of clinical investigation     Volume:  -     ISSN:  1365-2362     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.
Department of Gastroenterology, Marmara University, School of Medicine, Pendik, Istanbul, Turkey Institute of Gastroenterology, Marmara University, Maltepe, Istanbul, Turkey Department of Gastroenterology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey Department of Gastroenterology, Uludag University Medical School, Bursa, Turkey Department of Gastroenterology, Goztepe Education and Research Hospital, Istanbul, Turkey.
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