| Characterization of the non-invasive assessment of the cutaneous microcirculation by laser Doppler perfusion scanner. | |
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MedLine Citation:
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PMID: 20618693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Microcirculatory dysfunction contributes to morbidity and mortality in vascular diseases. Here, we aimed at establishing a sensitive and valid method to measure microvascular reactivity during post-occlusive reactive hyperemia (PORH) using scanning laser Doppler perfusion imaging (LDPI) of the forearm. METHODS: In a first series, LDPI was methodologically evaluated on the volar forearm of healthy volunteers (n = 10) before and after one to five minutes of upper arm occlusion. In a second series, readings were performed in 20 healthy subjects and 20 patients with coronary artery disease (CAD). RESULTS: Three minutes of forearm occlusion were sufficient to induce maximal vasodilation during PORH as indicated by maximal increase in perfusion unit (PU) amplitude that did not further increase after five-minute occlusion. Five-minute occlusion led to a significant prolongation of PORH with greater area under curve (AUC) suggesting longer lasting vasodilation of microvessels. The five-minute occlusion was associated with lower variability as compared with three minutes (intraindividual variability: 9-17% vs. 12-21%; interindividual variability: 13-24% vs. 14-26%). CAD patients exhibited significantly reduced amplitude (105 +/- 49 vs. 164 +/- 35 PU; p < 0.001), ratio (4.7 +/- 1.8 vs. 7.1 +/- 1.8; p < 0.001), and AUC (1656 +/- 1070 vs. 2723 +/- 864 PU x minutes; p = 0.001). CONCLUSION: Scanning LDPI is a feasible and reproducible method for non-invasive assessment of the cutaneous microcirculatory response during PORH. |
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Authors:
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Stefanie Keymel; Julia Sichwardt; Jan Balzer; Emilia Stegemann; Tienush Rassaf; Petra Kleinbongard; Malte Kelm; Christian Heiss; Thomas Lauer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: 17 ISSN: 1549-8719 ISO Abbreviation: Microcirculation Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: United States |
Other Details:
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Languages: eng Pagination: 358-66 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Cardiology, Pneumology, and Vascular Diseases, University Hospital, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Coronary Artery Disease / physiopathology Female Humans Hyperemia / physiopathology Laser-Doppler Flowmetry / methods* Male Microcirculation / physiology* Middle Aged Plethysmography Reproducibility of Results Skin / blood supply* Vasodilation / physiology Young Adult |
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