Document Detail


Characterization of nitrergic function in monkey penile erection in vivo and in vitro.
MedLine Citation:
PMID:  19498439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nitrergic nerve appears to have a major role in the neuronal regulation of penile erection. Cholinergic innervation has been shown histochemically in penile cavernous tissues, but its functional role is not well understood. This study was aimed at examining the functional properties of the nitrergic nerve and the possible involvement of cholinergic function in the regulation of monkey penile erection in vivo and in vitro. In anesthetized Japanese monkeys, electrical stimulation of the cavernous nerve caused a frequency-dependent increase in intracavernous pressure and penile erection, and atropine enhanced the pressure response. Intravenous injections of N(G)-nitro-L-arginine (L-NA) markedly inhibited the stimulation-induced pressure increase and the erectile response, and L-arginine partially restored the pressure response. In some monkeys, the intracavernous pressure increase caused by nerve stimulation was reversed by treatment with L-NA; however, L-arginine restored the pressor response. In addition, hexamethonium suppressed the pressure increase that resulted from the nerve stimulation. In corpus cavernosum isolated from monkeys, transmural electrical stimulation elicited frequency-dependent relaxation. The relaxation was attenuated by physostigmine, and was potentiated by atropine. Relaxation was markedly inhibited by treatment with L-NA. It appears that nitric oxide (NO) released from inhibitory nerves, even at low frequencies, has a pivotal role in the initiation and maintenance of intracavernous pressure increase and penile erection in monkeys. Prejunctional muscarinic receptors in nitrergic nerves are expected to participate in the impairment of NO release. Nitrergic nerves responsible for penile erection may originate from ganglia close to the corpus cavernosum.
Authors:
Kazuhide Ayajiki; Hideshi Hayashida; Masashi Tawa; Tomio Okamura; Noboru Toda
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-05
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  32     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  685-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Shiga University of Medical Science, Seta, Otsu 520-2192, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / physiology
Animals
Arginine / pharmacology
Blood Pressure / physiology
Electric Stimulation
Endothelium, Vascular / physiology
Enzyme Inhibitors / pharmacology
Hexamethonium / pharmacology
Macaca
Male
Nicotinic Antagonists / pharmacology
Nitric Oxide / physiology*
Nitric Oxide Synthase Type III / antagonists & inhibitors
Nitroarginine / pharmacology
Parasympatholytics / pharmacology
Parasympathomimetics / pharmacology
Penile Erection / physiology*
Penis / innervation,  physiology
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Nicotinic Antagonists; 0/Parasympatholytics; 0/Parasympathomimetics; 10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 51-84-3/Acetylcholine; 60-26-4/Hexamethonium; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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