| Characterization of nitrergic function in monkey penile erection in vivo and in vitro. | |
| | |
MedLine Citation:
|
PMID: 19498439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The nitrergic nerve appears to have a major role in the neuronal regulation of penile erection. Cholinergic innervation has been shown histochemically in penile cavernous tissues, but its functional role is not well understood. This study was aimed at examining the functional properties of the nitrergic nerve and the possible involvement of cholinergic function in the regulation of monkey penile erection in vivo and in vitro. In anesthetized Japanese monkeys, electrical stimulation of the cavernous nerve caused a frequency-dependent increase in intracavernous pressure and penile erection, and atropine enhanced the pressure response. Intravenous injections of N(G)-nitro-L-arginine (L-NA) markedly inhibited the stimulation-induced pressure increase and the erectile response, and L-arginine partially restored the pressure response. In some monkeys, the intracavernous pressure increase caused by nerve stimulation was reversed by treatment with L-NA; however, L-arginine restored the pressor response. In addition, hexamethonium suppressed the pressure increase that resulted from the nerve stimulation. In corpus cavernosum isolated from monkeys, transmural electrical stimulation elicited frequency-dependent relaxation. The relaxation was attenuated by physostigmine, and was potentiated by atropine. Relaxation was markedly inhibited by treatment with L-NA. It appears that nitric oxide (NO) released from inhibitory nerves, even at low frequencies, has a pivotal role in the initiation and maintenance of intracavernous pressure increase and penile erection in monkeys. Prejunctional muscarinic receptors in nitrergic nerves are expected to participate in the impairment of NO release. Nitrergic nerves responsible for penile erection may originate from ganglia close to the corpus cavernosum. |
| | |
Authors:
|
Kazuhide Ayajiki; Hideshi Hayashida; Masashi Tawa; Tomio Okamura; Noboru Toda |
Related Documents
:
|
17143189 - Long-term calcium antagonist treatment of human hypertension with mibefradil or amlodip... 23386889 - Prevalence of hypertension among the elderly malays living in rural malaysia. 23478099 - Genetic predisposition to higher blood pressure increases coronary artery disease risk. 6050109 - Centrally evoked sympathetic discharge: a functional study of medullary vasomotor areas. 11853869 - Cardiovascular actions of central neuromedin u in conscious rats. 23244359 - Effects of renal denervation on insulin resistance. 15672969 - Early diagnosis of trophoblast produced capillary hypertension (pregnancy-induced hyper... 17143189 - Long-term calcium antagonist treatment of human hypertension with mibefradil or amlodip... 6627959 - Clinical use of the arterial/alveolar oxygen tension ratio. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-05 |
Journal Detail:
|
Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 32 ISSN: 1348-4214 ISO Abbreviation: Hypertens. Res. Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-08-05 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: England |
Other Details:
|
Languages: eng Pagination: 685-9 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Shiga University of Medical Science, Seta, Otsu 520-2192, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
physiology Animals Arginine / pharmacology Blood Pressure / physiology Electric Stimulation Endothelium, Vascular / physiology Enzyme Inhibitors / pharmacology Hexamethonium / pharmacology Macaca Male Nicotinic Antagonists / pharmacology Nitric Oxide / physiology* Nitric Oxide Synthase Type III / antagonists & inhibitors Nitroarginine / pharmacology Parasympatholytics / pharmacology Parasympathomimetics / pharmacology Penile Erection / physiology* Penis / innervation, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Enzyme Inhibitors; 0/Nicotinic Antagonists; 0/Parasympatholytics; 0/Parasympathomimetics; 10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 51-84-3/Acetylcholine; 60-26-4/Hexamethonium; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term effect of efonidipine therapy on plasma aldosterone and left ventricular mass index in pat...
Next Document: Prediction of albuminuria by different blood pressure measurement methods in type 1 diabetes: a pilo...