| Characterization of the multiple sclerosis traits: Nuclear receptors (NR) impaired apoptosis pathway and the role of 1-alpha 25-dihydroxyvitamin D(3). | |
| | |
MedLine Citation:
|
PMID: 21752397 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Low expression of NR4A gene family members (NR4A1, NR4A3) and 1-alpha, 25-dihydroxyvitamin D(3) receptor (VDR) genes was demonstrated in peripheral blood mononuclear cells (PBMC) of subjects evaluated during the pre-disease state of multiple sclerosis (MS-to-be, MS2b), in patients with clinically isolated syndrome (CIS) during the very early presentation of neurological symptomatology and in relapsing-remitting MS (RRMS) patients. Both NR4A1 and NR4A3 are known to be involved in T-cell receptor-induced apoptosis and are regulated by VDR. We further evaluated the precise implications of apoptosis signaling regulators in relation to MS pathogenesis at the cellular level by studying the effects of 1-alpha, 25-dihydroxyvitamin D(3) (Vit D(3)) upon NR4A1 expression. We demonstrated that the low apoptotic level in MS patients was repaired by Vit D(3) mainly through NR4A1 and to a lesser extent thorough BCL2-associated X protein (BAX). These findings prove a role for Vit D(3) as a possible therapeutic intervention in MS patients aimed to activate the repressed apoptosis and enhance better control of the disease. |
| | |
Authors:
|
Anat Achiron; Anna Feldman; Michael Gurevich |
Related Documents
:
|
17936907 - Bovine tlr2 and tlr4 properly transduce signals from staphylococcus aureus and e. coli,... 19347047 - Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin... 17270147 - Staphylococcus aureus protein a induced inflammatory response in human corneal epitheli... 17100617 - Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response. 15203197 - Cell-induced copper ion-mediated low density lipoprotein oxidation increases during in ... 22172327 - Active lipids of ganoderma lucidum spores-induced apoptosis in human leukemia thp-1 cel... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-11 |
Journal Detail:
|
Title: Journal of the neurological sciences Volume: - ISSN: 1878-5883 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier B.V. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel mutation in the SCN4A responsible for cold-induced myotonia with normal electromyography fin...
Next Document: Emotion recognition impairment in Parkinson's disease patients without dementia.