Document Detail


Characterization and mechanisms of the pharyngoesophageal inhibitory reflex.
MedLine Citation:
PMID:  9815043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objectives of this study were to identify and to characterize the pharyngoesophageal inhibitory reflex (PEIR) in an animal model. Thirty-one cats (2.4-5.0 kg) were anesthetized using alpha-chloralose (45 mg/kg ip), and esophageal peristalsis was recorded manometrically. Secondary peristalsis was activated by rapid air injection (8-20 ml) at midesophagus or slow infusion of water through the manometric catheters. Neither stimulus activated primary peristalsis. The PEIR was activated by rapid water injection or focal mechanical stimulation of the pharynx. Rapid air injection activated secondary peristalsis in 92% of the trials, and slow water infusion activated 1 secondary peristalsis every 3.2 min. Pharyngeal stimulation by 0.3, 0.5, 0.8, or 1.0 ml of water inhibited or blocked ongoing secondary peristalsis in 67, 82, 97, or 93% of trials, respectively. Mechanical stimulation of the posterior wall of the pharynx with 11-20 g pressure attenuated secondary peristalsis in 96% of the trials or blocked secondary peristalsis in 41% of the trials. Centripetal electrical stimulation at 30 Hz, 0.2 ms, 2 V for 4 s of the superior laryngeal (SLN) or glossopharyngeal (GPN) nerves blocked or inhibited secondary peristalsis in 100% of the trials. Bilateral transection of the GPN (n = 8), but not the SLN (n = 6), blocked the PEIR. Anesthetization of the pharyngeal mucosa using lidocaine (2%) blocked the PEIR (n = 3). We concluded that 1) the PEIR exists in the cat, 2) mechanical stimulation of the pharynx more strongly activates the PEIR than water, 3) activation of either SLN or GPN afferents attenuates ongoing secondary peristalsis, 4) the receptors mediating the PEIR are located in the pharyngeal mucosa, and 5) both SLN and GPN contribute to the PEIR, but the GPN is the major afferent limb of this reflex.
Authors:
I M Lang; B K Medda; J Ren; R Shaker
Related Documents :
8309873 - Ultrasonography as a tool for monitoring in ovo chicken development. 2. effects of eggs...
25115633 - High plasma levels of hla-g are associated with low birth weight and with an increased ...
440893 - Apnea recordings of healthy infants at 40, 44, and 52 weeks postconception.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  275     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-12-14     Completed Date:  1998-12-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G1127-36     Citation Subset:  IM    
Affiliation:
Dysphagia Institute and Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Electric Stimulation
Electromyography
Esophagus / innervation,  physiology*
Glossopharyngeal Nerve / physiology
Laryngeal Nerves / physiology
Manometry
Mucous Membrane / physiology
Muscle, Smooth / physiology
Peristalsis / physiology*
Pharyngeal Muscles / innervation,  physiology*
Pharynx / innervation,  physiology*
Physical Stimulation
Pressure
Reflex / physiology*
Grant Support
ID/Acronym/Agency:
R01-DC-00669/DC/NIDCD NIH HHS; R01-DK-25731/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nitric oxide mediates hepatocyte injury.
Next Document:  Localization of cyclooxygenase-2 and regulation of its mRNA expression in gastric ulcers in rats.