| Characterization of maternal transfer of decabromodiphenyl ether (BDE-209) administered to pregnant Sprague-Dawley rats. | |
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MedLine Citation:
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PMID: 20851178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate maternal transfer of decabromodiphenyl ether (BDE-209), Sprague-Dawley rats were given daily oral doses of 5 μmol/kgb.w. BDE-209 in peanut oil from gestation day (GD) 7 to postpartum day (PD) 4. BDE-209 was increased temporally in maternal blood, placenta, fetuses and neonates. Furthermore, more BDE-209 was found in neonate whole-body samples obtained during lactational period (PD 4) than in that of fetal whole-body samples during pregnancy GD 15 and 21. Overall an increase was observed over time for nona-BDE levels in maternal blood and placenta, but these congeners were decreased in fetuses or neonates. Slight changes were observed for octa-BDEs in both maternal blood and placenta while a significant decrease was observed in the fetuses or neonates for BDE-196 and 198/203. These results demonstrated that BDE-209 and its metabolites can transport to the placenta and milk, and eventually enter the fetuses and/or the neonates. |
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Authors:
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Yunmei Cai; Wenbing Zhang; Junjie Hu; Guoying Sheng; Dunjin Chen; Jiamo Fu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-17 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 31 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-02-08 Completed Date: 2011-05-17 Revised Date: 2012-03-15 |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 106-10 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Wushan, Guangzhou 510640, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Animals, Newborn Female Fetus / drug effects*, metabolism Flame Retardants / pharmacokinetics*, toxicity Halogenated Diphenyl Ethers / pharmacokinetics*, toxicity Lactation / drug effects Maternal Exposure / adverse effects* Maternal-Fetal Exchange / drug effects*, physiology Milk Placenta / drug effects*, metabolism Pregnancy Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Flame Retardants; 0/Halogenated Diphenyl Ethers; 1163-19-5/decabromobiphenyl ether |
| Comments/Corrections | |
Comment In:
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Reprod Toxicol. 2012 Jan;33(1):116-7; author reply 118-9
[PMID:
22064312
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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