| Characterization and mapping of sleep-waking specific neurons in the basal forebrain and preoptic hypothalamus in mice. | |
| | |
MedLine Citation:
|
PMID: 19285545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We recorded 872 single units across the complete sleep-waking cycle in the mouse preoptic area (POA) and basal forebrain (BFB), which are deeply involved in the regulation of sleep and wakefulness (W). Of these, 552 were sleep-active, 96 were waking-active, 106 were active during both waking and paradoxical sleep (PS), and the remaining 118 were state-indifferent. Among the 872, we distinguished slow-wave sleep (SWS)-specific, SWS/PS-specific, PS-specific, W-specific, and W/PS-specific neurons, the last group being further divided into specific tonic type I slow (TI-Ss) and specific tonic type I rapid (TI-Rs) both discharging specifically in association with cortical activation during both W and PS. Both the SWS/PS-specific and PS-specific neurons were distributed throughout a wide region of the POA and BFB, whereas the SWS-specific neurons were mainly located in the middle and ventral half of the POA and adjacent BFB, as were the W-specific and W/PS-specific neurons. At the transition from waking to sleep, the majority of SWS-specific and all SWS/PS-specific neurons fired after the onset of cortical synchronization (deactivation), whereas all W-specific and W/PS-specific neurons showed a significant decrease in firing rate >0.5 s before the onset. At the transition from SWS to W, the sleep-specific neurons showed a significant decrease in firing rate 0.1 s before the onset of cortical activation, while the W-specific and W/PS-specific neurons fired >0.5 s before the onset. TI-Ss neurons were characterized by a triphasic broad action potential, slow single isolated firing, and an antidromic response to cortical stimulation, whereas TI-Rs neurons were characterized by a narrow action potential and high frequency burst discharge in association with theta waves in PS. These data suggest that the forebrain sleep/waking switch is regulated by opposing activities of sleep-promoting (SWS-specific and SWS/PS-specific) and waking-promoting (W-specific and W/PS-specific) neurons, that the initiation of sleep is caused by decreased activity of the waking-promoting neurons (disfacilitation), and that the W/PS-specific neurons are deeply involved in the processes of cortical activation/deactivation. |
| | |
Authors:
|
K Takahashi; J-S Lin; K Sakai |
Related Documents
:
|
13679145 - Changes in spontaneous neural activity immediately after an acoustic trauma: implicatio... 3253445 - Activation of feline spinal neurones by potentiated ventricular contractions and other ... 10981615 - Temporal processing in sensory systems. 9730055 - Abnormal neuroneal activities in intralaminar thalamic nuclei following chronic lesions... 17418955 - Group ii metabotropic glutamate receptors inhibit glutamate release at thalamocortical ... 10690975 - Mapping of functional organization in human visual cortex: electrical cortical stimulat... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-12 |
Journal Detail:
|
Title: Neuroscience Volume: 161 ISSN: 1873-7544 ISO Abbreviation: Neuroscience Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-05-11 Completed Date: 2009-09-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
|
Languages: eng Pagination: 269-92 Citation Subset: IM |
Affiliation:
|
INSERM U628, Lyon, F-69373, France and Claude Bernard University Lyon 1, 8 Avenue Rockefeller, Lyon Cedex 08, F-69373, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acoustic Stimulation Action Potentials Animals Brain Mapping Electric Stimulation Male Mice Mice, Inbred C57BL Neurons / physiology* Preoptic Area / cytology, physiology Prosencephalon / cytology*, physiology Sleep* Sleep Stages Wakefulness* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Visual motion direction is represented in population-level neural response as measured by magnetoenc...
Next Document: Ventrolateral prefrontal cortex activity associated with individual differences in arbitrary delayed...