Document Detail

Characterization of the major steroids present in amniotic fluid obtained between the 15th and 17th weeks of gestation.
MedLine Citation:
PMID:  6224976     Owner:  NLM     Status:  MEDLINE    
In pooled amniotic fluid obtained between the 15th and 17th weeks of gestation the concentration of free steroids and steroid glucuronides was found to be 40 micrograms/dl. The concentration of steroid monosulfates and disulfates was 19 micrograms/dl. About half of the characterized steroids are progesterone metabolites. The "fetal type" 3 beta-hydroxy-5-ene steroids were found exclusively in the sulfoconjugated form. Their concentration represents 20% of the total steroid content. The identification of two 15 beta-hydroxylated C21 steroids, 3 beta,15 beta,17 alpha-tridoxy-5-pregnen-20-one and 5-pregnene-3 beta,15 beta,17 alpha,20 alpha-tetrol isolated from mid-pregnancy amniotic fluid is reported here. Metabolites of cortisol and 17-deoxycorticosteroid metabolites had similar quantitative importance, 8.6 and 9.4%, respectively.
J Homoki; E Roitman; C H Shackleton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of steroid biochemistry     Volume:  19     ISSN:  0022-4731     ISO Abbreviation:  J. Steroid Biochem.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0260125     Medline TA:  J Steroid Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1061-8     Citation Subset:  IM    
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MeSH Terms
17-alpha-Hydroxypregnenolone / analysis
Adrenal Cortex Hormones / analysis*
Amniotic Fluid / analysis*
Corticosterone / analysis
Dehydroepiandrosterone / analogs & derivatives,  analysis
Estriol / analysis
Gestational Age*
Glucuronates / analysis
Hydrocortisone / analysis,  metabolism
Progesterone / analysis,  metabolism
Sulfates / analysis
Grant Support
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Glucuronates; 0/Sulfates; 1232-73-1/16-hydroxydehydroepiandrosterone; 387-79-1/17-alpha-Hydroxypregnenolone; 50-22-6/Corticosterone; 50-23-7/Hydrocortisone; 50-27-1/Estriol; 53-43-0/Dehydroepiandrosterone; 57-83-0/Progesterone

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