| Characterization of the major steroids present in amniotic fluid obtained between the 15th and 17th weeks of gestation. | |
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MedLine Citation:
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PMID: 6224976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In pooled amniotic fluid obtained between the 15th and 17th weeks of gestation the concentration of free steroids and steroid glucuronides was found to be 40 micrograms/dl. The concentration of steroid monosulfates and disulfates was 19 micrograms/dl. About half of the characterized steroids are progesterone metabolites. The "fetal type" 3 beta-hydroxy-5-ene steroids were found exclusively in the sulfoconjugated form. Their concentration represents 20% of the total steroid content. The identification of two 15 beta-hydroxylated C21 steroids, 3 beta,15 beta,17 alpha-tridoxy-5-pregnen-20-one and 5-pregnene-3 beta,15 beta,17 alpha,20 alpha-tetrol isolated from mid-pregnancy amniotic fluid is reported here. Metabolites of cortisol and 17-deoxycorticosteroid metabolites had similar quantitative importance, 8.6 and 9.4%, respectively. |
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Authors:
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J Homoki; E Roitman; C H Shackleton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of steroid biochemistry Volume: 19 ISSN: 0022-4731 ISO Abbreviation: J. Steroid Biochem. Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-10-08 Completed Date: 1983-10-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0260125 Medline TA: J Steroid Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1061-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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17-alpha-Hydroxypregnenolone
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analysis Adrenal Cortex Hormones / analysis* Amniotic Fluid / analysis* Corticosterone / analysis Dehydroepiandrosterone / analogs & derivatives, analysis Estriol / analysis Gestational Age* Glucuronates / analysis Humans Hydrocortisone / analysis, metabolism Progesterone / analysis, metabolism Sulfates / analysis |
| Grant Support | |
ID/Acronym/Agency:
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RR 00719/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Glucuronates; 0/Sulfates; 1232-73-1/16-hydroxydehydroepiandrosterone; 387-79-1/17-alpha-Hydroxypregnenolone; 50-22-6/Corticosterone; 50-23-7/Hydrocortisone; 50-27-1/Estriol; 53-43-0/Dehydroepiandrosterone; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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