| Characterization of magnetic nanoparticles using programmed quadrupole magnetic field-flow fractionation. | |
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MedLine Citation:
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PMID: 20732895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quadrupole magnetic field-flow fractionation is a relatively new technique for the separation and characterization of magnetic nanoparticles. Magnetic nanoparticles are often of composite nature having a magnetic component, which may be a very finely divided material, and a polymeric or other material coating that incorporates this magnetic material and stabilizes the particles in suspension. There may be other components such as antibodies on the surface for specific binding to biological cells, or chemotherapeutic drugs for magnetic drug delivery. Magnetic field-flow fractionation (MgFFF) has the potential for determining the distribution of the magnetic material among the particles in a given sample. MgFFF differs from most other forms of field-flow fractionation in that the magnetic field that brings about particle separation induces magnetic dipole moments in the nanoparticles, and these potentially can interact with one another and perturb the separation. This aspect is examined in the present work. Samples of magnetic nanoparticles were analysed under different experimental conditions to determine the sensitivity of the method to variation of conditions. The results are shown to be consistent and insensitive to conditions, although magnetite content appeared to be somewhat higher than expected. |
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Authors:
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P Stephen Williams; Francesca Carpino; Maciej Zborowski |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Volume: 368 ISSN: 1364-503X ISO Abbreviation: Philos Transact A Math Phys Eng Sci Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-24 Completed Date: 2010-09-28 Revised Date: 2011-12-09 |
Medline Journal Info:
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Nlm Unique ID: 101133385 Medline TA: Philos Transact A Math Phys Eng Sci Country: England |
Other Details:
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Languages: eng Pagination: 4419-37 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. willias3@ccf.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Delivery Systems Fractionation, Field Flow / instrumentation, methods* Magnetics* Metal Nanoparticles / chemistry* Models, Theoretical |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA062349-19/CA/NCI NIH HHS; R01 CA62349/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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