| Characterization and location of secretory phospholipase A2 groups IIE, V, and X in the rat brain. | |
| | |
MedLine Citation:
|
PMID: 16511882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Secretory phospholipases A(2) (sPLA(2)) form a diverse family of enzymes involved in a variety of physiologic and pathologic processes. Common among all sPLA(2) is the ability to cleave the second position of phospholipids, thereby releasing fatty acid and a lysophospholipid. Several sPLA(2) have been cloned and characterized in various tissues and receptors have been identified. In the nervous system, sPLA(2) groups IB, IIA, IIE, IIF, V, and XII have been identified, and binding sites for sPLA(2) have been found. Here, we report sPLA(2)-IIE and sPLA(2)-X in rat brain as well as in neurons in primary culture. We furthermore confirm the presence of sPLA(2)-V in rat brain and demonstrate the presence of sPLA(2)-V in primary neuronal cultures. The distribution of sPLA(2)-IIE, V, and -X seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus. We also find that sPLA(2)-IIE, -V, and -X are differentially induced by kainic acid. This study supports the concept that sPLA(2) heterogeneity in brain is functionally relevant and responsive to seizures. |
| | |
Authors:
|
Miriam Kolko; Nanna R Christoffersen; Sebastian G Barreiro; Martin L Miller; Andrew J Pizza; Nicolas G Bazan |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of neuroscience research Volume: 83 ISSN: 0360-4012 ISO Abbreviation: J. Neurosci. Res. Publication Date: 2006 Apr |
Date Detail:
|
Created Date: 2006-03-23 Completed Date: 2006-06-01 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: United States |
Other Details:
|
Languages: eng Pagination: 874-82 Citation Subset: IM |
Affiliation:
|
Neuroscience Center of Excellence, Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / physiology* Cells, Cultured Embryo, Mammalian Group II Phospholipases A2 Immunohistochemistry In Situ Hybridization Neurons / physiology* Phospholipases A / genetics*, metabolism* Phospholipases A2 Rats Reverse Transcriptase Polymerase Chain Reaction |
| Grant Support | |
ID/Acronym/Agency:
|
NS23002/NS/NINDS NIH HHS; NS46741/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Group II Phospholipases A2; EC 3.1.1.4/Phospholipases A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pre-sowing magnetic treatments of tomato seeds increase the growth and yield of plants.
Next Document: Epidemiologic characteristics of congenital diaphragmatic hernia among 2.5 million California births...