Document Detail

Characterization of late-pregnant rat uterine contraction via the contractility ratio in vitro significance of alpha1-adrenoceptors.
MedLine Citation:
PMID:  11228096     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to characterize the ability of late-pregnant (days 15-22) rat uterine tissue rings to contract in response to electric field stimulation in vitro. For this purpose, maximum rhythmic contractions were elicited by optimum choice of the period time and the pulse width, the two main parameters of electric field stimulation. In parallel, the plasma 17beta-estradiol and progesterone levels were determined. It was found that the contractility ratio, i.e. the quotient of the optimum pulse width and the period time, is a good parameter with which to express the contractility. The larger the contractility ratio, the better the ability to contract. Evaluation of the area under the curve did not furnish information relating to the contractility in this method. A very close correlation was observed between the contractility ratio and the quotient of the 17beta-estradiol and progesterone levels on different days, demonstrating that the in vitro ability characterized by the contractility ratio is in keeping with the physiological regularity. There was also a very close correlation between the contractility ratio and the quotient of the alpha1- and beta-adrenergic receptors, suggesting the main role of the numbers of alpha1-receptor in pregnant uterine contractility. It is believed that this is the first in vitro model to give a numerical measure concerning the ontogeny of uterine contractility in late pregnancy.
R Gáspár; I Földesi; J Havass; A Márki; G Falkay
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  68     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-28     Completed Date:  2001-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1119-29     Citation Subset:  IM    
Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Hungary.
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MeSH Terms
Calcium / metabolism
Electric Stimulation
Estradiol / blood
Pregnancy, Animal / physiology*
Progesterone / blood
Rats, Sprague-Dawley
Receptors, Adrenergic, alpha-1 / analysis,  physiology*
Receptors, Adrenergic, beta / analysis
Uterine Contraction*
Reg. No./Substance:
0/Receptors, Adrenergic, alpha-1; 0/Receptors, Adrenergic, beta; 50-28-2/Estradiol; 57-83-0/Progesterone; 7440-70-2/Calcium

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