Document Detail

Characterization of late incomplete stent apposition: a comparison among bare-metal stents, intracoronary radiation and sirolimus-eluting stents.
MedLine Citation:
PMID:  18180522     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Late incomplete stent apposition (LISA) develops following implantation of conventional bare-metal stents (BMS) or drug-eluting stents, or after adjunctive intracoronary radiation (IR). However, no study has systematically compared the morphology of LISA seen with various treatment modalities. PURPOSE: To compare the morphometric features of LISA accompanying BMS, IR or sirolimus-eluting stents (SES) using serial intravascular ultrasound (IVUS). METHODS: A query of Stanford University's IVUS database of the Cardiovascular Core Analysis Laboratory was performed to identify LISA cases. Dedicated software programs were used for volumetric IVUS analyses. RESULTS: In 30 LISA cases (12 BMS, 6 IR and 12 SES), there was no intertreatment difference in the degree of LISA (lumen area minus stent area at follow up). Serial analyses of LISA segments showed that vessel area of SES and IR showed significant increase at follow up as compared with post procedure, while there was no significant change in plaque area. In contrast, the BMS group showed no increase in vessel area, whereas plaque area revealed significant reduction. Eight of 12 BMS cases were treated by directional atherectomy before stenting; however, there was no difference in the area change between patients with or without pre-stent atherectomy. Post-procedure plaque thickness beneath the stent struts of LISA was thinner for SES as compared with BMS. CONCLUSIONS: Plaque reduction primarily contributes to LISA after BMS, whereas vessel expansion is the predominant factor in LISA development for IR and SES. Thus, the mechanism of LISA may vary among different interventional treatments.
Akiyoshi Miyazawa; Ichizo Tsujino; Junya Ako; Yoshihisa Shimada; Brian K Courtney; Ryota Sakurai; Mamoo Nakamura; Hiroyuki Okura; Katsuhisa Waseda; Yasuhiro Honda; Peter J Fitzgerald
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  19     ISSN:  1557-2501     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-08     Completed Date:  2008-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-8     Citation Subset:  IM    
Center for Cardiovascular Technology, Stanford University Medical Center, 300 Pasteur Drive, Room H3554, Stanford, CA, 94305, USA.
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MeSH Terms
Blood Vessel Prosthesis Implantation / instrumentation*
Coated Materials, Biocompatible*
Coronary Restenosis / therapy*,  ultrasonography
Coronary Vessels / radiation effects*,  ultrasonography
Follow-Up Studies
Graft Occlusion, Vascular / prevention & control,  ultrasonography
Immunosuppressive Agents / pharmacology
Prospective Studies
Sirolimus / pharmacology*
Treatment Outcome
Ultrasonography, Interventional
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Immunosuppressive Agents; 0/Metals; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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