Document Detail


Characterization of laryngeal dysfunction in chronic persistent cough.
MedLine Citation:
PMID:  19205007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES/HYPOTHESIS: Laryngeal symptoms are increasingly recognized to occur in chronic persistent cough and may result from the sensory hyperresponsiveness that characterizes this condition. Apart from cough, the motor consequences of sensory activation have not been well described in chronic persistent cough. The efficacy of speech pathology treatment for chronic cough suggests that laryngeal dysfunction may be relevant in chronic persistent cough. This study investigated the relationship between cough reflex sensitivity and laryngeal dysfunction, which was assessed as paradoxical vocal cord movement (PVCM) and extrathoracic airway hyperresponsiveness, in patients with chronic cough. STUDY DESIGN: Cross-sectional case-control comparison of subjects with chronic cough and healthy controls. METHODS: Adults with chronic persistent cough (n = 25) and healthy controls (n = 11) were assessed by cough-specific quality of life questionnaire, extrathoracic airway hyperresponsiveness to hypertonic saline provocation, capsaicin cough reflex hypersensitivity, and fibreoptic laryngoscopy to assess PVCM. RESULTS: Laryngeal dysfunction was present in many patients with chronic persistent cough. PVCM was present in 56% of subjects with chronic cough and accompanied by cough reflex hypersensitivity and impaired quality of life. Inspiratory airflows were reduced in cough with PVCM, and there was significant extrathoracic airway hyperresponsiveness. CONCLUSIONS: Laryngeal dysfunction is common in chronic cough, where it is manifest as paradoxical vocal cord movement and extrathoracic airway hyperresponsiveness. Laryngeal dysfunction in chronic cough is associated with reduced quality of life. Laryngeal hypersensitivity may be a common mechanism that can be effectively treated by speech language therapy.
Authors:
Nicole M Ryan; Peter G Gibson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Laryngoscope     Volume:  119     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-31     Completed Date:  2009-04-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  640-5     Citation Subset:  IM    
Affiliation:
Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, University of Newcastle, Newcastle, 2308, NSW, Australia. nicole.ryan@newcastle.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Case-Control Studies
Causality
Chronic Disease
Comorbidity
Cough / epidemiology*
Cross-Sectional Studies
Female
Humans
Laryngeal Diseases / epidemiology*,  pathology
Laryngitis / diagnosis,  epidemiology,  pathology
Male
Middle Aged
New South Wales / epidemiology
Quality of Life
Respiratory Hypersensitivity / epidemiology
Sputum / cytology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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