| Characterization of laryngeal dysfunction in chronic persistent cough. | |
| | |
MedLine Citation:
|
PMID: 19205007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES/HYPOTHESIS: Laryngeal symptoms are increasingly recognized to occur in chronic persistent cough and may result from the sensory hyperresponsiveness that characterizes this condition. Apart from cough, the motor consequences of sensory activation have not been well described in chronic persistent cough. The efficacy of speech pathology treatment for chronic cough suggests that laryngeal dysfunction may be relevant in chronic persistent cough. This study investigated the relationship between cough reflex sensitivity and laryngeal dysfunction, which was assessed as paradoxical vocal cord movement (PVCM) and extrathoracic airway hyperresponsiveness, in patients with chronic cough. STUDY DESIGN: Cross-sectional case-control comparison of subjects with chronic cough and healthy controls. METHODS: Adults with chronic persistent cough (n = 25) and healthy controls (n = 11) were assessed by cough-specific quality of life questionnaire, extrathoracic airway hyperresponsiveness to hypertonic saline provocation, capsaicin cough reflex hypersensitivity, and fibreoptic laryngoscopy to assess PVCM. RESULTS: Laryngeal dysfunction was present in many patients with chronic persistent cough. PVCM was present in 56% of subjects with chronic cough and accompanied by cough reflex hypersensitivity and impaired quality of life. Inspiratory airflows were reduced in cough with PVCM, and there was significant extrathoracic airway hyperresponsiveness. CONCLUSIONS: Laryngeal dysfunction is common in chronic cough, where it is manifest as paradoxical vocal cord movement and extrathoracic airway hyperresponsiveness. Laryngeal dysfunction in chronic cough is associated with reduced quality of life. Laryngeal hypersensitivity may be a common mechanism that can be effectively treated by speech language therapy. |
| | |
Authors:
|
Nicole M Ryan; Peter G Gibson |
Related Documents
:
|
22270997 - Evaluation of postoperative radioactive iodine scans in patients who underwent prophyla... 20673037 - Frequent chronic obstructive pulmonary disease exacerbators: how much real, how much fi... 21789477 - Successful treatment with bosentan for pulmonary hypertension and reduced peripheral ci... 2109557 - Eucapnia and hypercapnia in patients with chronic airflow limitation. the role of the u... 16358967 - Soluble form of trail, fas and fasl in the serum of patients with b-cll. 6689947 - Effect of transfusion therapy on arteriographic abnormalities and on recurrence of stro... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Laryngoscope Volume: 119 ISSN: 1531-4995 ISO Abbreviation: Laryngoscope Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-03-31 Completed Date: 2009-04-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
|
Languages: eng Pagination: 640-5 Citation Subset: IM |
Affiliation:
|
Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, University of Newcastle, Newcastle, 2308, NSW, Australia. nicole.ryan@newcastle.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Case-Control Studies Causality Chronic Disease Comorbidity Cough / epidemiology* Cross-Sectional Studies Female Humans Laryngeal Diseases / epidemiology*, pathology Laryngitis / diagnosis, epidemiology, pathology Male Middle Aged New South Wales / epidemiology Quality of Life Respiratory Hypersensitivity / epidemiology Sputum / cytology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adaptive modelling of dose-response relationships using smoothing splines.
Next Document: Microsatellite DNA instability in nasal polyposis.