| Characterization of keratan sulfate isolated from liver affected by Morquio syndrome. | |
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MedLine Citation:
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PMID: 6222514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chemical structures of keratan sulfate (KS) isolated from the liver affected by Morquio syndrome type A (classical type) were investigated. In the KS from Morquio syndrome liver, the molar ratios of hexose, total sulfate, N-sulfate and sialic acid to hexosamine were 5.07, 0.90, 0.18 and 0.08, respectively, and about 10% of hexosamine consisted of galactosamine. The KS resulted in a production of oligosaccharides of relatively larger size after digestion with keratanase, as compared with bovine corneal KS. These findings strongly suggest that KS accumulated in the liver affected by Morquio syndrome may be derived from bony KS. |
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Authors:
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R Minami; T Ikeno; C Igarashi; S Tsugawa; T Nakao |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Tohoku journal of experimental medicine Volume: 139 ISSN: 0040-8727 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 1983 Mar |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 321-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone and Bones / metabolism Cattle Chemical Phenomena Chemistry Cornea / analysis Glycosaminoglycans / isolation & purification* Humans Keratan Sulfate / isolation & purification*, metabolism Liver / analysis* Molecular Weight Mucopolysaccharidosis IV / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Glycosaminoglycans; 9056-36-4/Keratan Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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