Document Detail


Characterization of the insulin-like growth factor (IGF) axis in the serum of maternal and fetal macaques (Macaca mulatta and Macaca fascicularis).
MedLine Citation:
PMID:  8745144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The insulin-like growth factors (IGFs) are key effectors of fetal growth and development which are modulated by serum carrier proteins (IGF binding proteins [IGFBPs]). Studies were performed to evaluate the developmental profile of IGFs and IGFBPs in the macaque, an important nonhuman primate model for human development and disease. IGF-I, IGF-II, and IGFBP-3 were studied in the rhesus (Macaca mulatta) and long-tailed (Macaca fascicularis) monkey fetus and dam during the second and third trimesters of pregnancy. Serial fetal blood samples were collected by cardiocentesis every 10 days from gestational day (GD) 90-160, and at 1 month postnatal age; maternal blood samples were collected at similar timepoints. Results indicated that maternal sera IGF-I and IGF-II did not change significantly whereas fetal concentrations of serum IGF-I and IGF-II increased approximately two-fold during the second to the third trimesters. No significant differences were detected between the two species. Western-ligand blot analysis revealed predominant IGFBPs of 45-40 (IGFBP-3) and 28 kDa (IGFBP-1) in both the maternal and fetal compartments, and Western-immunoblot analysis using a specific antisera against IGFBP-3 indicated 45-40 and 28 kDa immunoreactive forms. Thus, although IGF-I, IGF-II, and IGFBP-3 remained relatively unaffected in maternal sera during this period of gestation, fetal concentrations of IGF-I, IGF-II, and IGFBP-3 increased in a developmental profile similar to the human fetus.
Authors:
A F Tarantal; S E Gargosky
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Growth regulation     Volume:  5     ISSN:  0956-523X     ISO Abbreviation:  Growth Regul.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-10-11     Completed Date:  1996-10-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9106990     Medline TA:  Growth Regul     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  190-8     Citation Subset:  IM    
Affiliation:
California Regional Primate Research Center, University of California, Davis, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
Bone and Bones / embryology
Embryonic and Fetal Development*
Female
Fetal Blood / chemistry*
Gestational Age
Humans
Insulin-Like Growth Factor Binding Protein 3 / blood*
Insulin-Like Growth Factor I / analysis,  metabolism*
Insulin-Like Growth Factor II / analysis,  metabolism*
Macaca fascicularis
Macaca mulatta
Pregnancy
Pregnancy, Animal / blood*
Species Specificity
Grant Support
ID/Acronym/Agency:
AI32299 RR00169/AI/NIAID NIH HHS; HD25528/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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