| Characterization of inositol 1,3,4-trisphosphate phosphorylation in rat liver. | |
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MedLine Citation:
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PMID: 2841169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Liver homogenates phosphorylated Ins 1,3,4-P3 to an InsP4 isomer that was distinct from Ins 1,3,4,5-P4. This InsP4 isomer accumulated in vasopressin stimulated hepatocytes prelabeled with myo-[3H]inositol with a time course that lagged behind Ins 1,3,4-P3 formation. The Ins 1,3,4-P3 kinase responsible for its formation was partially purified from rat liver. The enzyme had a Km for Ins 1,3,4-P3 of 0.29 microM, a Km for ATP of 141 microM and was not affected by changes in free Ca2+ in the physiological range. The relationship of this new InsP4 isomer to the inositol phosphate signaling pathway is discussed. |
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Authors:
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C A Hansen; S vom Dahl; B Huddell; J R Williamson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: FEBS letters Volume: 236 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-09-20 Completed Date: 1988-09-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 53-6 Citation Subset: IM |
Affiliation:
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University of Pennsylvania School of Medicine, Department of Biochemistry and Biophysics, Philadelphia 19104. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, High Pressure Liquid Hydrogen-Ion Concentration Inositol 1,4,5-Trisphosphate Inositol Phosphates / metabolism* Isomerism Lithium / pharmacology Liver / metabolism* Phosphorylation Phosphotransferases / analysis Phosphotransferases (Alcohol Group Acceptor)* Rats Sugar Phosphates / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DK-15120/DK/NIDDK NIH HHS; DK-19525/DK/NIDDK NIH HHS; HL-07146/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Inositol Phosphates; 0/Sugar Phosphates; 7439-93-2/Lithium; 85166-31-0/Inositol 1,4,5-Trisphosphate; EC 2.7.-/Phosphotransferases; EC 2.7.1.-/Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.133/myo-inositol-trisphosphate 6-kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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