| Characterization of the in vivo action of (R)-salsolinol, an endogenous metabolite of alcohol, on serotonin and dopamine metabolism: a microdialysis study. | |
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MedLine Citation:
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PMID: 8050034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using a microdialysis-HPLC technique in conscious rats, we examined the action of (R)-1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol (R-Sal), a possible endogenous metabolite of alcohol, on serotonin (5-HT) and dopamine (DA) metabolism in four regions of the brain: the striatum, the substantia nigra, the hippocampus and the hypothalamus. Following 1 mM R-Sal perfusion, the dialysate level of 5-HT in the striatum markedly increased from non-detectable levels to 4259.2 +/- 617.5 nM, while DA increased from 3.4 +/- 0.9 nM to 206.0 +/- 56.5 nM. This increase was one order of magnitude larger in 5-HT than in DA. Conversely, the output of 5-hydroxyindoleacetic acid decreased markedly to non-detectable levels, while 3,4-dihydroxyphenylacetic acid and homovanillic acid outputs decreased below 40% of basal levels. These effects were dose-related to R-Sal (1 microM to 1 mM) and were confirmed also in 3 other brain regions. The R-Sal-induced responses in the striatum were observed even after pretreatment of 2 microM tetrodotoxin, a blocker of nerve-firing activity, via the dialysis membrane. The repetitive perfusion with 1 mM R-Sal into the striatum induced the reproducible response of 5-HT and DA. Furthermore, the potencies of 1 mM R-Sal to increase the output of 5-HT and DA were approximately 783.0-fold and 2.6-fold stronger, respectively, than those of the same dose of methamphetamine. The results suggest that R-Sal acts to stimulate a release of monoamines, 5-HT preferentially, with inhibition of monoamine oxidase and catechol-O-methyltransferase activities. |
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Authors:
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D Nakahara; W Maruyama; H Hashiguti; M Naoi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 644 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-09-08 Completed Date: 1994-09-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 226-32 Citation Subset: IM |
Affiliation:
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Department of Psychology, Nagoya University College of Medical Technology, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Animals Biogenic Monoamines / metabolism Brain Chemistry / drug effects* Catecholamines / metabolism, physiology Chromatography, High Pressure Liquid Dopamine / metabolism*, physiology Ethanol / metabolism* Isoquinolines / pharmacology* Male Methamphetamine / pharmacology Microdialysis Neurons / metabolism Rats Rats, Wistar Serotonin / metabolism*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Biogenic Monoamines; 0/Catecholamines; 0/Isoquinolines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 50-67-9/Serotonin; 525-72-4/salsolinol; 537-46-2/Methamphetamine; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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