| Characterization of in vitro proliferative responses of human lymphocytes to leishmanial antigens. | |
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MedLine Citation:
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PMID: 90105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leishmaniasis is an intracellular protozoal infection for which host defense is believed to depend on cellular immune mechanisms. The in vitro proliferative responses of lymphocytes from patients with leishmaniasis and from control subjects to leishmanial antigens were examined. Only lymphocytes from patients responded to 1 microgram of leishmanial antigen/ml, whereas both patient and control lymphocytes responded to 10 micrograms/ml. The nonspecific responses were most likely not due to a mitogenic component in the antigen preparation because cord blood lymphocytes failed to respond at all concentrations of antigen tested. Both specific and nonspecific responses to leishmanial antigens were elicited in purified populations of thymus-derived (T) cells. This lymphocyte proliferation assay can be applied to the assessment of antigen-specific responsiveness of T cells from patients who represent the spectrum of host defense against leishmaniasis. |
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Authors:
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D J Wyler; F I Weinbaum; H R Herrod |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 140 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1979 Aug |
Date Detail:
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Created Date: 1979-11-29 Completed Date: 1979-11-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 215-21 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antigens Epitopes Female Humans Leishmania / immunology* Leishmaniasis / immunology Lymphocyte Activation* Male Middle Aged T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Epitopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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