Document Detail

Characterization of impurities in the bulk drug lisinopril by liquid chromatography/ion trap spectrometry.
MedLine Citation:
PMID:  18500778     Owner:  NLM     Status:  MEDLINE    
Two trace impurities in the bulk drug lisinopril were detected by means of high-performance liquid chromatography coupled with mass spectrometry (HPLC/MS) with a simple and sensitive method suitable for HPLC/MSn analysis. The fragmentation behavior of lisinopril and the impurities was investigated, and two unknown impurities were elucidated as 2-(6-amino-1-(1-carboxyethylamino)-1-oxohexan-2-ylamino)-4-phenylbutanoic acid and 6-amino-2-(1-carboxy-3-phenylpro-pylamino)-hexanoic acid on the basis of the multi-stage mass spectrometry and exact mass evidence. The proposed structures of the two unknown impurities were further confirmed by nuclear magnetic resonance (NMR) experiments after preparative isolation.
Pei-xi Zhu; Dan-hua Wang; Cui-rong Sun; Zhi-quan Shen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  9     ISSN:  1673-1581     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-07-24     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  385-90     Citation Subset:  IM    
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
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MeSH Terms
Chromatography, High Pressure Liquid / methods*
Drug Contamination*
Lisinopril / analysis*
Magnetic Resonance Spectroscopy
Spectrometry, Mass, Electrospray Ionization / methods*
Reg. No./Substance:

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