Document Detail

Characterization of immune cells in kidneys from patients with Sjogren's syndrome.
MedLine Citation:
PMID:  3276169     Owner:  NLM     Status:  MEDLINE    
The association of interstitial nephritis, the most common renal lesion in Sjogren's syndrome, to the other manifestations of the disease is unclear. To begin to address this issue, the infiltrating cells in frozen kidney tissues from two patients with interstitial nephritis secondary to Sjogren's syndrome were characterized by indirect immunofluorescence. T cells predominated, the majority of which were helper/inducer cells (OKT4+). Both kidneys contained nodules of B cells. The increased proportion of OKT4+ T cells in salivary gland and in interstitial renal lesions of Sjogren's syndrome contrasts with some other forms of interstitial renal disease and suggests that the renal and salivary gland lesions have a similar pathogenesis.
M E Rosenberg; P B Schendel; F A McCurdy; J L Platt
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  11     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-02-24     Completed Date:  1988-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20-2     Citation Subset:  IM    
Department of Medicine, University of Minnesota, Minneapolis 55455.
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MeSH Terms
B-Lymphocytes / classification
Fluorescent Antibody Technique
Kidney / pathology*
Middle Aged
Nephritis, Interstitial / etiology,  pathology*
Sjogren's Syndrome / complications,  pathology*
T-Lymphocytes / classification
Grant Support

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