Document Detail


Characterization of imidazopyrroloquinoline compounds synthesized from coenzyme PQQ and various amino acids.
MedLine Citation:
PMID:  8722120     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Imidazopyrroloquinoline (IPQ) compounds synthesized from coenzyme PQQ (pyrroloquinoline quinone) and various kinds of amino acids were characterized. IPQ was synthesized from coenzyme PQQ and one of three amino acids (glycine, L-tryptophan and L-tyrosine). Two kinds of IPQ compound were formed from coenzyme PQQ and L-serine. At higher pH, IPQ was synthesized, at lower pH hydroxy-methyl-IPQ was synthesized. IPQ with R of amino acids represented by R-CH(NH2)-COOH was synthesized from coenzyme PQQ and other amino acids. IPQ compounds do not act as cofactor of glucose dehydrogenase. Molar absorption coefficients of IPQ are 31,400 M-1 cm-1 at 251 nm, 30,700 M-1 cm-1 at 276 nm, and 20,700 M-1 cm-1 at 423 nm at pH 7.0 and room temperature.
Authors:
T Urakami; K Sugamura; E Niki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  5     ISSN:  0951-6433     ISO Abbreviation:  Biofactors     Publication Date:    1995-1996
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2006-07-19    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Affiliation:
Biochemicals Division, Mitsubishi Gas Chemical Co., Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*
Glycine / chemistry
Imidazoles / chemical synthesis*,  chemistry
Molecular Structure
PQQ Cofactor
Pyrroles / chemical synthesis*,  chemistry
Quinolines / chemical synthesis*,  chemistry
Quinolones / chemistry*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Imidazoles; 0/Pyrroles; 0/Quinolines; 0/Quinolones; 56-40-6/Glycine; 72909-34-3/PQQ Cofactor

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