Document Detail

Characterization of imidazopyrroloquinoline compounds synthesized from coenzyme PQQ and various amino acids.
MedLine Citation:
PMID:  8722120     Owner:  NLM     Status:  MEDLINE    
Imidazopyrroloquinoline (IPQ) compounds synthesized from coenzyme PQQ (pyrroloquinoline quinone) and various kinds of amino acids were characterized. IPQ was synthesized from coenzyme PQQ and one of three amino acids (glycine, L-tryptophan and L-tyrosine). Two kinds of IPQ compound were formed from coenzyme PQQ and L-serine. At higher pH, IPQ was synthesized, at lower pH hydroxy-methyl-IPQ was synthesized. IPQ with R of amino acids represented by R-CH(NH2)-COOH was synthesized from coenzyme PQQ and other amino acids. IPQ compounds do not act as cofactor of glucose dehydrogenase. Molar absorption coefficients of IPQ are 31,400 M-1 cm-1 at 251 nm, 30,700 M-1 cm-1 at 276 nm, and 20,700 M-1 cm-1 at 423 nm at pH 7.0 and room temperature.
T Urakami; K Sugamura; E Niki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  5     ISSN:  0951-6433     ISO Abbreviation:  Biofactors     Publication Date:    1995-1996
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2006-07-19    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Biochemicals Division, Mitsubishi Gas Chemical Co., Tokyo, Japan.
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MeSH Terms
Amino Acids / chemistry*
Glycine / chemistry
Imidazoles / chemical synthesis*,  chemistry
Molecular Structure
PQQ Cofactor
Pyrroles / chemical synthesis*,  chemistry
Quinolines / chemical synthesis*,  chemistry
Quinolones / chemistry*
Reg. No./Substance:
0/Amino Acids; 0/Imidazoles; 0/Pyrroles; 0/Quinolines; 0/Quinolones; 56-40-6/Glycine; 72909-34-3/PQQ Cofactor

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