Document Detail

Characterization of hyperparathyroidism in youth and adolescents: a literature review.
MedLine Citation:
PMID:  23313432     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To systematically review the preoperative diagnostic modalities, surgical treatments, and glandular pathologies associated with primary hyperparathyroidism in children and adolescents under 20 years of age.
METHODS: We searched PUBMED, Cochrane databases, OVID, Web of Science (SCIE and SSCI), CINAHL, and Health Source: Nursing academic for articles involving surgical management of primary hyperparathyroidism in the pediatric population on 5/2012.
SELECTION CRITERIA: Literature review, database review, and retrospective review studies date were used from 1986 until 2012. Ages ranged for 0-19 years old.
RESULTS: Of the 230 cases of pediatric primary hyperparathyroidism reported since 1987, solitary adenomas (SA), multiple gland hyperplasia disease (MGHD), double adenomas (DA), and normal parathyroid gland pathology occurred in 80%, 16.5%, 0.9%, and 2.6% respectively. Of the MGHD patients (38 pts), 1/2 (19 pts) of the cases were attributed to MEN I, MEN II, or familial non MEN hyperparathyroidism. Tc(99m)-sestamibi and ultrasound were 86% (37/43) and 74.5% (70/94) sensitive, respectively for localizing parathyroid disease.
CONCLUSIONS: Limited data exists on pediatric and adolescent patients with primary hyperparathyroidism. Sufficient data exists demonstrating single adenomas are most common and young patients are usually more symptomatic than adults. One may conclude that spontaneous primary hyperparathyroidism may be approached and managed similarly to adults. The incidence of primary hyperparathyroidism in this population may be under appreciated and a lower threshold for ordering a screening serum calcium should be considered.
Ryan Belcher; Aaron M Metrailer; Donald L Bodenner; Brendan C Stack
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-11
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  77     ISSN:  1872-8464     ISO Abbreviation:  Int. J. Pediatr. Otorhinolaryngol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-11     Completed Date:  2013-08-13     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  318-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Hyperparathyroidism / pathology*,  surgery
Parathyroid Glands / pathology*,  surgery
Parathyroid Neoplasms / complications,  pathology*
Young Adult

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